8vvg
From Proteopedia
(Difference between revisions)
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- | '''Unreleased structure''' | ||
- | + | ==Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18== | |
- | + | <StructureSection load='8vvg' size='340' side='right'caption='[[8vvg]], [[Resolution|resolution]] 3.30Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[8vvg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VVG FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
- | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AD5:methyl+(2S,3R,3aS,4S,5aS,9aS,9bS)-3-methyl-2-[(2S,6S)-6-methylpiperidin-2-yl]dodecahydro-3,5a-epoxycyclopenta[a]naphthalene-4-carboxylate'>A1AD5</scene></td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vvg OCA], [https://pdbe.org/8vvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vvg RCSB], [https://www.ebi.ac.uk/pdbsum/8vvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vvg ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Gati C]] | ||
+ | [[Category: Han GW]] | ||
+ | [[Category: Khan S]] | ||
+ | [[Category: Majumdar S]] | ||
+ | [[Category: Motiwala Z]] | ||
+ | [[Category: Ramos-Gonzalez N]] | ||
+ | [[Category: Shenvi R]] | ||
+ | [[Category: Styrpejko D]] | ||
+ | [[Category: Tyson AS]] |
Current revision
Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18
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Categories: Homo sapiens | Large Structures | Gati C | Han GW | Khan S | Majumdar S | Motiwala Z | Ramos-Gonzalez N | Shenvi R | Styrpejko D | Tyson AS