9h0b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) receptor binding domain in complex with porcine DPEP1.== | |
| - | + | <StructureSection load='9h0b' size='340' side='right'caption='[[9h0b]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9h0b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_hemagglutinating_encephalomyelitis_virus Porcine hemagglutinating encephalomyelitis virus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H0B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h0b OCA], [https://pdbe.org/9h0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h0b RCSB], [https://www.ebi.ac.uk/pdbsum/9h0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h0b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPEP1_PIG DPEP1_PIG] Hydrolyzes a wide range of dipeptides (PubMed:8045301, PubMed:8823187). Hydrolyzes the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (By similarity).[UniProtKB:P31428]<ref>PMID:8045301</ref> <ref>PMID:8823187</ref> Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.[UniProtKB:P31428] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Porcine hemagglutinating encephalomyelitis virus]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Fernandez I]] | ||
| + | [[Category: Rey F]] | ||
Current revision
Crystal structure of the Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) receptor binding domain in complex with porcine DPEP1.
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