9jto

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(New page: '''Unreleased structure''' The entry 9jto is ON HOLD until Paper Publication Authors: Chen, Q., Zhao, Y., Wang, Y. Description: Glucose 6 phosphate catalytic subunit 1-substrate [[Cate...)
Current revision (05:44, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jto is ON HOLD until Paper Publication
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==Human glucose 6 phosphate catalytic subunit 1 (hG6PC1) bound with F6P.==
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<StructureSection load='9jto' size='340' side='right'caption='[[9jto]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Chen, Q., Zhao, Y., Wang, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JTO FirstGlance]. <br>
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Description: Glucose 6 phosphate catalytic subunit 1-substrate
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
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[[Category: Zhao, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jto OCA], [https://pdbe.org/9jto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jto RCSB], [https://www.ebi.ac.uk/pdbsum/9jto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jto ProSAT]</span></td></tr>
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[[Category: Wang, Y]]
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</table>
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[[Category: Chen, Q]]
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== Disease ==
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[https://www.uniprot.org/uniprot/G6PC1_HUMAN G6PC1_HUMAN] Glycogen storage disease due to glucose-6-phosphatase deficiency type Ia. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/G6PC1_HUMAN G6PC1_HUMAN] Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.<ref>PMID:10960498</ref> <ref>PMID:12093795</ref> <ref>PMID:15542400</ref> <ref>PMID:9332655</ref> <ref>PMID:9497333</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Q]]
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[[Category: Wang Y]]
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[[Category: Zhao Y]]

Current revision

Human glucose 6 phosphate catalytic subunit 1 (hG6PC1) bound with F6P.

PDB ID 9jto

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