9h49

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m (Protected "9h49" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9h49 is ON HOLD
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==Crystal structure of the adduct between human serum transferrin (apo-form) and cisplatin==
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<StructureSection load='9h49' size='340' side='right'caption='[[9h49]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
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Authors: Troisi, R., Galardo, F., Ferraro, G., Sica, F., Merlino, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9h49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H49 FirstGlance]. <br>
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Description: Crystal structure of the adduct between human serum transferrin (apo form) and cisplatin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.52&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NH3:AMMONIA'>NH3</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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[[Category: Galardo, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h49 OCA], [https://pdbe.org/9h49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h49 RCSB], [https://www.ebi.ac.uk/pdbsum/9h49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h49 ProSAT]</span></td></tr>
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[[Category: Sica, F]]
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</table>
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[[Category: Ferraro, G]]
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== Disease ==
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[[Category: Troisi, R]]
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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[[Category: Merlino, A]]
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ferraro G]]
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[[Category: Galardo F]]
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[[Category: Merlino A]]
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[[Category: Sica F]]
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[[Category: Troisi R]]

Current revision

Crystal structure of the adduct between human serum transferrin (apo-form) and cisplatin

PDB ID 9h49

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