9ijw
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Serine protease inhibitor HCIQ2c1 from Heteractis crispa with TRPA1 mediated antinociceptive activity== | |
| - | + | <StructureSection load='9ijw' size='340' side='right'caption='[[9ijw]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ijw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Radianthus_crispa Radianthus crispa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IJW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ijw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ijw OCA], [https://pdbe.org/9ijw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ijw RCSB], [https://www.ebi.ac.uk/pdbsum/9ijw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ijw ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VKT2I_RADCR VKT2I_RADCR] Serine protease inhibitor that also shows protective effect in a cytotoxicity model (PubMed:32144281). It binds to all proteases tested (trypsin (Ki=52 nM), alpha-chymotrypsin, cathepsin G, kallikrein, and human neutrophil elastase) (PubMed:32144281). It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:32144281, PubMed:35563513). It also seems to protect cells by inhibiting ATP-induced purinoceptor (P2RX7) activation (PubMed:35563513).<ref>PMID:32144281</ref> <ref>PMID:35563513</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Radianthus crispa]] | ||
| + | [[Category: Leychenko EV]] | ||
| + | [[Category: Lyukmanova EN]] | ||
| + | [[Category: Menshov AS]] | ||
| + | [[Category: Mironov PA]] | ||
| + | [[Category: Oreshkov SD]] | ||
| + | [[Category: Paramonov AS]] | ||
| + | [[Category: Shenkarev ZO]] | ||
Current revision
Serine protease inhibitor HCIQ2c1 from Heteractis crispa with TRPA1 mediated antinociceptive activity
| |||||||||||
