9jgz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of Human Kcnk13.== | |
| - | + | <StructureSection load='9jgz' size='340' side='right'caption='[[9jgz]], [[Resolution|resolution]] 2.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9jgz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JGZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=D21:[(2~{R})-1-hexadecanoyloxy-3-phosphonooxy-propan-2-yl]+octadec-9-enoate'>D21</scene>, <scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr> |
| - | [[Category: Baobin | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jgz OCA], [https://pdbe.org/9jgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jgz RCSB], [https://www.ebi.ac.uk/pdbsum/9jgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jgz ProSAT]</span></td></tr> |
| - | [[Category: Jin | + | </table> |
| - | [[Category: Ran | + | == Function == |
| + | [https://www.uniprot.org/uniprot/KCNKD_HUMAN KCNKD_HUMAN] K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687). Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity) (PubMed:38409076).[UniProtKB:Q8R1P5]<ref>PMID:24163367</ref> <ref>PMID:25148687</ref> <ref>PMID:30472253</ref> <ref>PMID:38409076</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baobin L]] | ||
| + | [[Category: Jin W]] | ||
| + | [[Category: Ran Z]] | ||
Current revision
Cryo-EM Structure of Human Kcnk13.
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Categories: Homo sapiens | Large Structures | Baobin L | Jin W | Ran Z
