9jxd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9jxd is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human XPR1 in apo state== | |
| - | + | <StructureSection load='9jxd' size='340' side='right'caption='[[9jxd]], [[Resolution|resolution]] 3.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9jxd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JXD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jxd OCA], [https://pdbe.org/9jxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jxd RCSB], [https://www.ebi.ac.uk/pdbsum/9jxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jxd ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/S53A1_HUMAN S53A1_HUMAN] Bilateral striopallidodentate calcinosis. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S53A1_HUMAN S53A1_HUMAN] Inorganic ion transporter that mediates phosphate ion export across plasma membrane. Plays a major role in phosphate homeostasis, preventing intracellular phosphate accumulation and possible calcium phosphate precipitation, ultimately preserving calcium signaling. The molecular mechanism of phosphate transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated (By similarity) (PubMed:23791524, PubMed:25938945, PubMed:31043717). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7), important intracellular signaling molecules involved in regulation of phosphate flux (PubMed:27080106).[UniProtKB:Q9Z0U0]<ref>PMID:23791524</ref> <ref>PMID:25938945</ref> <ref>PMID:27080106</ref> <ref>PMID:31043717</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bai Z]] | ||
| + | [[Category: Corry B]] | ||
| + | [[Category: Gu C]] | ||
| + | [[Category: Han Y]] | ||
| + | [[Category: Jessen H]] | ||
| + | [[Category: Jin R]] | ||
| + | [[Category: Lei M]] | ||
| + | [[Category: Shears S]] | ||
| + | [[Category: Sun Y]] | ||
| + | [[Category: Wallis C]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Cryo-EM structure of human XPR1 in apo state
| |||||||||||
