1tqi

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[[Image:1tqi.gif|left|200px]]
 
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==Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase==
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The line below this paragraph, containing "STRUCTURE_1tqi", creates the "Structure Box" on the page.
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<StructureSection load='1tqi' size='340' side='right'caption='[[1tqi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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{{STRUCTURE_1tqi| PDB=1tqi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqi OCA], [https://pdbe.org/1tqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqi RCSB], [https://www.ebi.ac.uk/pdbsum/1tqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqi ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase'''
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== Function ==
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[https://www.uniprot.org/uniprot/RIO2_ARCFU RIO2_ARCFU]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serine phosphorylation in vitro, and the presence of conserved catalytic residues is required for cell viability. The activity of Rio2 is necessary for rRNA cleavage in 40S ribosomal subunit maturation. We solved the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 A resolution. The C-terminal RIO domain is indeed structurally homologous to protein kinases, although it differs from known serine kinases in ATP binding and lacks the regions important for substrate binding. Unexpectedly, the N-terminal Rio2-specific domain contains a winged helix fold, seen primarily in DNA-binding proteins. These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqi_consurf.spt"</scriptWhenChecked>
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1TQI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQI OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases., LaRonde-LeBlanc N, Wlodawer A, Structure. 2004 Sep;12(9):1585-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341724 15341724]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqi ConSurf].
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[[Category: Archaeoglobus fulgidus dsm 4304]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: LaRonde-LeBlanc, N.]]
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</StructureSection>
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[[Category: Wlodawer, A.]]
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[[Category: Archaeoglobus fulgidus DSM 4304]]
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[[Category: Serine kinase]]
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[[Category: Large Structures]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:15:21 2008''
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[[Category: LaRonde-LeBlanc N]]
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[[Category: Wlodawer A]]

Current revision

Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase

PDB ID 1tqi

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