9k6l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of GPCR16-Gi2 complex== | |
| - | + | <StructureSection load='9k6l' size='340' side='right'caption='[[9k6l]], [[Resolution|resolution]] 2.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9k6l]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K6L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SA0:2-(HYDROXYMETHYL)PHENYL+BETA-D-GLUCOPYRANOSIDE'>SA0</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k6l OCA], [https://pdbe.org/9k6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k6l RCSB], [https://www.ebi.ac.uk/pdbsum/9k6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k6l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI2_HUMAN GNAI2_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.<ref>PMID:17635935</ref> Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.<ref>PMID:17550964</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptococcus pneumoniae]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Hua T]] | ||
| + | [[Category: Liu ZJ]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Wu LJ]] | ||
| + | [[Category: Zhou C]] | ||
Current revision
Cryo-EM structure of GPCR16-Gi2 complex
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