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1tvt

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[[Image:1tvt.jpg|left|200px]]
 
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==STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1tvt", creates the "Structure Box" on the page.
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<StructureSection load='1tvt' size='340' side='right'caption='[[1tvt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TVT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvt OCA], [https://pdbe.org/1tvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tvt RCSB], [https://www.ebi.ac.uk/pdbsum/1tvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tvt ProSAT]</span></td></tr>
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{{STRUCTURE_1tvt| PDB=1tvt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O89467_9RETR O89467_9RETR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tv/1tvt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tvt ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN'''
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==See Also==
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*[[Tat protein|Tat protein]]
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__TOC__
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==Overview==
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</StructureSection>
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Trans-activator (Tat) proteins regulate the transcription of lentiviral DNA in the host cell genome. These RNA binding proteins participate in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). The consensus RNA binding motifs [the trans-activation responsive element (TAR)] of HIV-1 as well as EIAV Tat proteins are well characterized. The structure of the 75-amino acid EIAV Tat protein in solution was determined by two- and three-dimensional nuclear magnetic resonance methods and molecular dynamics calculations. The protein structure exhibits a well-defined hydrophobic core of 15 amino acids that serves as a scaffold for two flexible domains corresponding to the NH2- and COOH-terminal regions. The core region is a strictly conserved sequence region among the known Tat proteins. The structural data can be used to explain several of the observed features of Tat proteins.
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==About this Structure==
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1TVT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVT OCA].
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==Reference==
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Structure of the equine infectious anemia virus Tat protein., Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P, Science. 1994 Jun 10;264(5165):1584-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7515512 7515512]
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[[Category: Equine infectious anemia virus]]
[[Category: Equine infectious anemia virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Roesch, P.]]
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[[Category: Roesch P]]
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[[Category: Willbold, D.]]
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[[Category: Willbold D]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:26:00 2008''
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Current revision

STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN

PDB ID 1tvt

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