1u12

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[[Image:1u12.gif|left|200px]]
 
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==M. loti cyclic nucleotide binding domain mutant==
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The line below this paragraph, containing "STRUCTURE_1u12", creates the "Structure Box" on the page.
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<StructureSection load='1u12' size='340' side='right'caption='[[1u12]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u12]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_japonicum_MAFF_303099 Mesorhizobium japonicum MAFF 303099]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U12 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1u12| PDB=1u12 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u12 OCA], [https://pdbe.org/1u12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u12 RCSB], [https://www.ebi.ac.uk/pdbsum/1u12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u12 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CNGK1_RHILO CNGK1_RHILO] Cyclic nucleotide-regulated potassium channel activated by cAMP.<ref>PMID:15550244</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u12_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u12 ConSurf].
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<div style="clear:both"></div>
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'''M. loti cyclic nucleotide binding domain mutant'''
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Overview==
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<references/>
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Here we describe the initial functional characterization of a cyclic nucleotide regulated ion channel from the bacterium Mesorhizobium loti and present two structures of its cyclic nucleotide binding domain, with and without cAMP. The domains are organized as dimers with the interface formed by the linker regions that connect the nucleotide binding pocket to the pore domain. Together, structural and functional data suggest the domains form two dimers on the cytoplasmic face of the channel. We propose a model for gating in which ligand binding alters the structural relationship within a dimer, directly affecting the position of the adjacent transmembrane helices.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1U12 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti_maff303099 Mesorhizobium loti maff303099]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U12 OCA].
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[[Category: Mesorhizobium japonicum MAFF 303099]]
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[[Category: Clayton GM]]
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==Reference==
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[[Category: Heginbotham L]]
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Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel., Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH, Cell. 2004 Nov 24;119(5):615-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15550244 15550244]
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[[Category: Morais-Cabral JH]]
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[[Category: Mesorhizobium loti maff303099]]
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[[Category: Silverman WR]]
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[[Category: Single protein]]
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[[Category: Clayton, G M.]]
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[[Category: Heginbotham, L.]]
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[[Category: Morais-Cabral, J H.]]
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[[Category: Silverman, W R.]]
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[[Category: C-helix mutation]]
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[[Category: Mutant cyclic nucleotide binding domain]]
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[[Category: Unliganded]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:37:18 2008''
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Current revision

M. loti cyclic nucleotide binding domain mutant

PDB ID 1u12

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