9h9j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9h9j is ON HOLD Authors: Schedlbauer, A., Han, X., van Bakel, W., Kaminishi, T., Ochoa-Lizarralde, B., Iturrioz, I., Capuni, R., Parry, R., Zegarra,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex 2 (BODY) 30S-IF1-IF3-tRNA-GE81112== | |
| - | + | <StructureSection load='9h9j' size='340' side='right'caption='[[9h9j]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9h9j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H9J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=A1IC4:(2~{S},3~{S})-2-[[(2~{S})-2-[[(2~{S},4~{S})-5-aminocarbonyloxy-4-oxidanyl-2-[[(2~{S},3~{R})-3-oxidanylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-3-(1~{H}-imidazol-4-yl)propanoyl]amino]-3-(2-chloranyl-1~{H}-imidazol-4-yl)-3-oxidanyl-propanoic+acid'>A1IC4</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h9j OCA], [https://pdbe.org/9h9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h9j RCSB], [https://www.ebi.ac.uk/pdbsum/9h9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h9j ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/RS4_ECOLI RS4_ECOLI] One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> |
| - | [[Category: Fucini | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Barragan Sanz K]] |
| - | [[Category: | + | [[Category: Brandi L]] |
| - | [[Category: | + | [[Category: Capuni R]] |
| - | [[Category: | + | [[Category: Connell SR]] |
| - | [[Category: | + | [[Category: Fucini P]] |
| - | [[Category: | + | [[Category: Gil-Carton D]] |
| + | [[Category: Gualerzi CO]] | ||
| + | [[Category: Han X]] | ||
| + | [[Category: Iturrioz I]] | ||
| + | [[Category: Kaminishi T]] | ||
| + | [[Category: Lopez-Alonso JP]] | ||
| + | [[Category: Ochoa-Lizarralde B]] | ||
| + | [[Category: Parry R]] | ||
| + | [[Category: Schedlbauer A]] | ||
| + | [[Category: Zegarra R]] | ||
| + | [[Category: Van Bakel W]] | ||
Current revision
Complex 2 (BODY) 30S-IF1-IF3-tRNA-GE81112
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