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1u6h

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[[Image:1u6h.gif|left|200px]]
 
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==Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)==
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The line below this paragraph, containing "STRUCTURE_1u6h", creates the "Structure Box" on the page.
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<StructureSection load='1u6h' size='340' side='right'caption='[[1u6h]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U6H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6h OCA], [https://pdbe.org/1u6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u6h RCSB], [https://www.ebi.ac.uk/pdbsum/1u6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6h ProSAT]</span></td></tr>
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{{STRUCTURE_1u6h| PDB=1u6h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VINC_CHICK VINC_CHICK] Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.<ref>PMID:15229287</ref> <ref>PMID:20584916</ref> <ref>PMID:20086044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6h ConSurf].
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<div style="clear:both"></div>
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'''Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)'''
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==See Also==
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*[[Talin 3D structures|Talin 3D structures]]
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*[[Vinculin 3D structures|Vinculin 3D structures]]
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==Overview==
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== References ==
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The cytoskeletal protein talin plays a key role in activating integrins and in coupling them to the actin cytoskeleton. Its N-terminal globular head, which binds beta integrins, is linked to an extended rod having a C-terminal actin binding site and several vinculin binding sites (VBSs). The NMR structure of residues 755-889 of the rod (containing a VBS) is shown to be an amphipathic four-helix bundle with a left-handed topology. A talin peptide corresponding to the VBS binds the vinculin head; the X-ray crystallographic structure of this complex shows that the residues which interact with vinculin are buried in the hydrophobic core of the talin fragment. NMR shows that the interaction involves a major structural change in the talin fragment, including unfolding of one of its helices, making the VBS accessible to vinculin. Interestingly, the talin 755-889 fragment binds more than one vinculin head molecule, suggesting that the talin rod may contain additional as yet unrecognized VBSs.
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1U6H is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6H OCA].
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==Reference==
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A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head., Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL, Structure. 2005 Jan;13(1):65-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15642262 15642262]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Barsukov, I L.]]
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[[Category: Barsukov IL]]
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[[Category: Critchley, D R.]]
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[[Category: Critchley DR]]
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[[Category: Emsley, J.]]
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[[Category: Emsley J]]
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[[Category: Fillingham, I.]]
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[[Category: Fillingham I]]
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[[Category: Gingras, A R.]]
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[[Category: Gingras AR]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: Patel, B.]]
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[[Category: Patel B]]
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[[Category: Roberts, G C.K.]]
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[[Category: Roberts GCK]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:49:00 2008''
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Current revision

Vinculin head (0-258) in complex with the talin vinculin binding site 2 (849-879)

PDB ID 1u6h

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