8yd1

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'''Unreleased structure'''
 
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The entry 8yd1 is ON HOLD until Paper Publication
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==CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1==
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<StructureSection load='8yd1' size='340' side='right'caption='[[8yd1]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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Authors: Zhou, B., Zhao, H., Gao, Y., Chen, X., Zhang, T., He, J., Xiong, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8yd1]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_grunniens Bos grunniens] and [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YD1 FirstGlance]. <br>
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Description: CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BO2:N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE'>BO2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Zhou, B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yd1 OCA], [https://pdbe.org/8yd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yd1 RCSB], [https://www.ebi.ac.uk/pdbsum/8yd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yd1 ProSAT]</span></td></tr>
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[[Category: Xiong, X]]
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</table>
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[[Category: Zhao, H]]
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== Function ==
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[[Category: Zhang, T]]
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[https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref>
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[[Category: He, J]]
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== References ==
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[[Category: Gao, Y]]
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<references/>
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[[Category: Chen, X]]
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__TOC__
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</StructureSection>
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[[Category: Bos grunniens]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Chen X]]
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[[Category: Gao Y]]
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[[Category: He J]]
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[[Category: Xiong X]]
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[[Category: Zhang T]]
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[[Category: Zhao H]]
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[[Category: Zhou B]]

Current revision

CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1

PDB ID 8yd1

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