9hb8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor KM-06-098== | |
| - | + | <StructureSection load='9hb8' size='340' side='right'caption='[[9hb8]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9hb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HB8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.896342Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=UVU:3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione'>UVU</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hb8 OCA], [https://pdbe.org/9hb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hb8 RCSB], [https://www.ebi.ac.uk/pdbsum/9hb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hb8 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Mallow | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. |
| - | [[Category: Specker | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Heinemann U]] | ||
| + | [[Category: Mallow K]] | ||
| + | [[Category: Nazare M]] | ||
| + | [[Category: Schuetz A]] | ||
| + | [[Category: Specker E]] | ||
Current revision
Crystal structure of human tryptophan hydroxylase 2 in complex with inhibitor KM-06-098
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