1xud

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(New page: 200px<br /> <applet load="1xud" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xud, resolution 1.800&Aring;" /> '''Matrix metalloprot...)
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[[Image:1xud.gif|left|200px]]<br />
 
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<applet load="1xud" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xud, resolution 1.800&Aring;" />
 
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'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''<br />
 
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==Overview==
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==Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor==
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The paradigm for matrix metalloprotease inhibition combines active site, tailoring and catalytic zinc ligation. But, selectivity has been, difficult. Now, Engel et al. present novel compounds, completely selective, for MMP-13, with a unique binding mode.
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<StructureSection load='1xud' size='340' side='right'caption='[[1xud]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PB4:N,N-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xud OCA], [https://pdbe.org/1xud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xud RCSB], [https://www.ebi.ac.uk/pdbsum/1xud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xud ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:[https://omim.org/entry/602111 602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.<ref>PMID:16167086</ref> Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:[https://omim.org/entry/602111 602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.<ref>PMID:19615667</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP13_HUMAN MMP13_HUMAN] Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xud_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xud ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1XUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA and PB4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA].
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15734640 15734640]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Engel, C.K.]]
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[[Category: Engel CK]]
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[[Category: Wendt, K.U.]]
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[[Category: Wendt KU]]
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[[Category: CA]]
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[[Category: PB4]]
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[[Category: ZN]]
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[[Category: matrix metalloproteinase]]
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[[Category: non-zinc binding inhibitor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:11:11 2007''
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Current revision

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

PDB ID 1xud

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