1uct

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[[Image:1uct.jpg|left|200px]]
 
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==Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)==
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The line below this paragraph, containing "STRUCTURE_1uct", creates the "Structure Box" on the page.
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<StructureSection load='1uct' size='340' side='right'caption='[[1uct]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UCT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uct OCA], [https://pdbe.org/1uct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uct RCSB], [https://www.ebi.ac.uk/pdbsum/1uct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uct ProSAT]</span></td></tr>
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{{STRUCTURE_1uct| PDB=1uct | SCENE= }}
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</table>
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== Function ==
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'''Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)'''
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[https://www.uniprot.org/uniprot/FCAR_HUMAN FCAR_HUMAN] Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1uct_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uct ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.
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==About this Structure==
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Crystal structure of the ectodomain of human FcalphaRI.,Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:12783876<ref>PMID:12783876</ref>
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1UCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCT OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of the ectodomain of human FcalphaRI., Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z, J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12783876 12783876]
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</div>
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<div class="pdbe-citations 1uct" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ding, Y.]]
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[[Category: Ding Y]]
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[[Category: Rao, Z.]]
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[[Category: Rao Z]]
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[[Category: Xu, G.]]
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[[Category: Xu G]]
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[[Category: Yang, M.]]
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[[Category: Yang M]]
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[[Category: Zhang, W.]]
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[[Category: Zhang W]]
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[[Category: Beta stand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:03:00 2008''
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Current revision

Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)

PDB ID 1uct

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