9ko4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A Cryo_EM structure of CCR7 complex with CCL21== | |
| - | + | <StructureSection load='9ko4' size='340' side='right'caption='[[9ko4]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ko4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KO4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ko4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ko4 OCA], [https://pdbe.org/9ko4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ko4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ko4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ko4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CCL21_HUMAN CCL21_HUMAN] Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao Y]] | ||
| + | [[Category: Duan J]] | ||
| + | [[Category: Yuan Q]] | ||
Current revision
A Cryo_EM structure of CCR7 complex with CCL21
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Categories: Homo sapiens | Large Structures | Cao Y | Duan J | Yuan Q
