9kos
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9kos is ON HOLD Authors: Lan, J., Wang, C.H. Description: Crystal structure of RaTG13 RBD complexed with sheep ACE2 [[Category: Unreleased Structur...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RaTG13 RBD complexed with sheep ACE2== | |
| - | + | <StructureSection load='9kos' size='340' side='right'caption='[[9kos]], [[Resolution|resolution]] 3.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9kos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_coronavirus_RaTG13 Bat coronavirus RaTG13] and [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KOS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.74Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kos OCA], [https://pdbe.org/9kos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kos RCSB], [https://www.ebi.ac.uk/pdbsum/9kos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kos ProSAT]</span></td></tr> |
| - | [[Category: Lan | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A6P3TFC0_SHEEP A0A6P3TFC0_SHEEP] Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.[ARBA:ARBA00056418] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bat coronavirus RaTG13]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ovis aries]] | ||
| + | [[Category: Lan J]] | ||
| + | [[Category: Wang CH]] | ||
Current revision
Crystal structure of RaTG13 RBD complexed with sheep ACE2
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