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1ulg

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[[Image:1ulg.jpg|left|200px]]
 
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==CGL2 in complex with Thomsen-Friedenreich antigen==
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The line below this paragraph, containing "STRUCTURE_1ulg", creates the "Structure Box" on the page.
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<StructureSection load='1ulg' size='340' side='right'caption='[[1ulg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ulg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ULG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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{{STRUCTURE_1ulg| PDB=1ulg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ulg OCA], [https://pdbe.org/1ulg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ulg RCSB], [https://www.ebi.ac.uk/pdbsum/1ulg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ulg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CGL2_COPCI CGL2_COPCI] Binds lactose. May play a role in fruiting body formation.<ref>PMID:8999822</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ul/1ulg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ulg ConSurf].
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<div style="clear:both"></div>
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'''CGL2 in complex with Thomsen-Friedenreich antigen'''
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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==Overview==
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<references/>
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Recognition of and discrimination between potential glyco-substrates is central to the function of galectins. Here we dissect the fundamental parameters responsible for such selectivity by the fungal representative, CGL2. The 2.1 A crystal structure of CGL2 and five substrate complexes reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft. Kinetic studies on wild-type and mutant CGL2 proteins demonstrate that the tetrameric organization is essential for functionality. The geometric constraints due to the orthogonal orientation of the four binding sites have important consequences on substrate binding and selectivity.
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__TOC__
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</StructureSection>
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==About this Structure==
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1ULG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Coprinopsis_cinerea Coprinopsis cinerea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ULG OCA].
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==Reference==
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Structure and functional analysis of the fungal galectin CGL2., Walser PJ, Haebel PW, Kunzler M, Sargent D, Kues U, Aebi M, Ban N, Structure. 2004 Apr;12(4):689-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15062091 15062091]
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[[Category: Coprinopsis cinerea]]
[[Category: Coprinopsis cinerea]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aebi, M.]]
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[[Category: Aebi M]]
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[[Category: Ban, N.]]
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[[Category: Ban N]]
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[[Category: Haebel, P W.]]
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[[Category: Haebel PW]]
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[[Category: Kuenzler, M.]]
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[[Category: Kuenzler M]]
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[[Category: Kues, U.]]
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[[Category: Kues U]]
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[[Category: Walser, P J.]]
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[[Category: Walser PJ]]
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[[Category: Beta-galactoside binding lectin]]
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[[Category: Galectin]]
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[[Category: Lectin]]
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[[Category: Sugar binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:23:22 2008''
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Current revision

CGL2 in complex with Thomsen-Friedenreich antigen

PDB ID 1ulg

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