9hin

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(New page: '''Unreleased structure''' The entry 9hin is ON HOLD Authors: Lenz, C., Haman, A., Spissinger, H., Knapp, S., Kraemer, A., Structural Genomics Consortium (SGC) Description: Crystal str...)
Current revision (06:25, 15 January 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hin is ON HOLD
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==Crystal structure of human TRIM7 PRYSPRY domain bound to ((S)-2-(6-(6-methoxypyridin-3-yl)-1-oxoisoindolin-2-yl)-3-phenylpropanoyl)-L-glutamine==
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<StructureSection load='9hin' size='340' side='right'caption='[[9hin]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors: Lenz, C., Haman, A., Spissinger, H., Knapp, S., Kraemer, A., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HIN FirstGlance]. <br>
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Description: Crystal structure of human TRIM7 PRYSPRY domain bound to ((S)-2-(6-(6-methoxypyridin-3-yl)-1-oxoisoindolin-2-yl)-3-phenylpropanoyl)-L-glutamine
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IU9:(2~{S})-5-azanyl-2-[[(2~{S})-2-[5-(6-methoxypyridin-3-yl)-3-oxidanylidene-1~{H}-isoindol-2-yl]-3-phenyl-propanoyl]amino]-5-oxidanylidene-pentanoic+acid'>A1IU9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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[[Category: Kraemer, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hin OCA], [https://pdbe.org/9hin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hin RCSB], [https://www.ebi.ac.uk/pdbsum/9hin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hin ProSAT]</span></td></tr>
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[[Category: Spissinger, H]]
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</table>
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[[Category: Haman, A]]
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== Function ==
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[[Category: Lenz, C]]
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[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>
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[[Category: Knapp, S]]
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== References ==
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[[Category: Structural Genomics Consortium (Sgc)]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Haman A]]
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[[Category: Knapp S]]
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[[Category: Kraemer A]]
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[[Category: Lenz C]]
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[[Category: Spissinger H]]

Current revision

Crystal structure of human TRIM7 PRYSPRY domain bound to ((S)-2-(6-(6-methoxypyridin-3-yl)-1-oxoisoindolin-2-yl)-3-phenylpropanoyl)-L-glutamine

PDB ID 9hin

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