9el5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==FANCM translocase domain bound to DNA== | |
| - | + | <StructureSection load='9el5' size='340' side='right'caption='[[9el5]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9el5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EL5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9el5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9el5 OCA], [https://pdbe.org/9el5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9el5 RCSB], [https://www.ebi.ac.uk/pdbsum/9el5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9el5 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: | + | == Function == |
| - | [[Category: Chapman | + | [https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] |
| - | [[Category: Deans | + | == References == |
| - | [[Category: Murphy | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Abbouche L]] | ||
| + | [[Category: Bythell-Douglas R]] | ||
| + | [[Category: Chapman K]] | ||
| + | [[Category: Deans AJ]] | ||
| + | [[Category: Murphy V]] | ||
| + | [[Category: Rigoreau L]] | ||
| + | [[Category: Wolf J]] | ||
Current revision
FANCM translocase domain bound to DNA
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