9hlc

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m (Protected "9hlc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9hlc is ON HOLD
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==TRPML1 in complex with compound 11==
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<StructureSection load='9hlc' size='340' side='right'caption='[[9hlc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hlc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HLC FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8K6:OCTADECANE'>8K6</scene>, <scene name='pdbligand=A1IV5:(8~{R},9~{S},13~{S},14~{S},17~{S})-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol'>A1IV5</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=EUJ:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,4,6-tris(oxidanyl)-3,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>EUJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hlc OCA], [https://pdbe.org/9hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hlc RCSB], [https://www.ebi.ac.uk/pdbsum/9hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hlc ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Clark M]]
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[[Category: Cowan SR]]
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[[Category: Di Daniel E]]
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[[Category: Earl CP]]
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[[Category: Fisher S]]
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[[Category: Holvey RS]]
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[[Category: Jackson SM]]
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[[Category: Johnson CN]]
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[[Category: Lloyd-Evans E]]
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[[Category: Mahajan P]]
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[[Category: Morgillo CM]]
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[[Category: Mortenson PN]]
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[[Category: O'Reilly M]]
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[[Category: Reeks J]]
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[[Category: Richardson CJ]]
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[[Category: Schopf P]]
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[[Category: Tams DM]]
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[[Category: Waller-Evans H]]
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[[Category: Ward SE]]
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[[Category: Whibley S]]
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[[Category: Williams PA]]

Current revision

TRPML1 in complex with compound 11

PDB ID 9hlc

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OCA

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