1y96

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(New page: 200px<br /> <applet load="1y96" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y96, resolution 2.002&Aring;" /> '''crystal structure ...)
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[[Image:1y96.gif|left|200px]]<br />
 
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<applet load="1y96" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1y96, resolution 2.002&Aring;" />
 
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'''crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex'''<br />
 
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==Overview==
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==crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex==
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The survival of motor neurons (SMN) protein, product of the disease gene, of the common neurodegenerative disease spinal muscular atrophy, is part, of the large multiprotein "SMN complex." The SMN complex functions as an, assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major, components of the spliceosome. Here, we report the crystal structure of, two components of the human SMN complex, Gemin6 and Gemin7. Although, Gemin6 and Gemin7 have no significant sequence similarity with Sm, proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist, as a heterodimer, and interact with each other via an interface similar to, that which mediates interactions among the Sm proteins. Together with, binding experiments that show that the Gemin6/Gemin7 complex binds to Sm, proteins, these findings provide a framework for considering how the SMN, complex, with Gemin6 and Gemin7 as tools, might organize Sm proteins for, formation of Sm rings on snRNA targets.
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<StructureSection load='1y96' size='340' side='right'caption='[[1y96]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1y96]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y96 FirstGlance]. <br>
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1Y96 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y96 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y96 OCA], [https://pdbe.org/1y96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y96 RCSB], [https://www.ebi.ac.uk/pdbsum/1y96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y96 ProSAT]</span></td></tr>
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==Reference==
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</table>
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The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure., Ma Y, Dostie J, Dreyfuss G, Van Duyne GD, Structure. 2005 Jun;13(6):883-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15939020 15939020]
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== Function ==
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[https://www.uniprot.org/uniprot/GEMI6_HUMAN GEMI6_HUMAN] The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.<ref>PMID:11748230</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y9/1y96_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y96 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Dostie, J.]]
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[[Category: Dostie J]]
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[[Category: Dreyfuss, G.]]
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[[Category: Dreyfuss G]]
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[[Category: Duyne, G.D.Van.]]
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[[Category: Ma Y]]
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[[Category: Ma, Y.]]
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[[Category: Van Duyne GD]]
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[[Category: protein complex]]
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[[Category: sm fold]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:16:39 2007''
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Current revision

crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex

PDB ID 1y96

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