9kz4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9kz4 is ON HOLD Authors: Zhang, K.C., Chen, Z.X. Description: Dihydrofolate reductase binding to NADPH and trimethoprim-tetramethylrhodamine [[Cate...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Dihydrofolate reductase binding to NADPH and trimethoprim-tetramethylrhodamine== | |
| - | + | <StructureSection load='9kz4' size='340' side='right'caption='[[9kz4]], [[Resolution|resolution]] 1.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9kz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KZ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.708Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EHX:[9-[5-[2-[4-[[2,4-bis(azanyl)pyrimidin-5-yl]methyl]-2,6-dimethoxy-phenoxy]ethylcarbamoyl]-2-carboxy-phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethyl-azanium'>A1EHX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> |
| - | [[Category: Chen | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kz4 OCA], [https://pdbe.org/9kz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kz4 RCSB], [https://www.ebi.ac.uk/pdbsum/9kz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kz4 ProSAT]</span></td></tr> |
| - | [[Category: Zhang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen ZX]] | ||
| + | [[Category: Zhang KC]] | ||
Current revision
Dihydrofolate reductase binding to NADPH and trimethoprim-tetramethylrhodamine
| |||||||||||
