1upx

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[[Image:1upx.jpg|left|200px]]
 
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==The crystal structure of the Hybrid Cluster Protein from Desulfovibrio desulfuricans containing molecules in the oxidized and reduced states.==
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The line below this paragraph, containing "STRUCTURE_1upx", creates the "Structure Box" on the page.
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<StructureSection load='1upx' size='340' side='right'caption='[[1upx]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1upx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UPX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FSO:IRON/SULFUR/OXYGEN+HYBRID+CLUSTER'>FSO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_1upx| PDB=1upx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1upx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upx OCA], [https://pdbe.org/1upx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1upx RCSB], [https://www.ebi.ac.uk/pdbsum/1upx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1upx ProSAT]</span></td></tr>
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</table>
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'''THE CRYSTAL STRUCTURE OF THE HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO DESULFURICANS CONTAINING MOLECULES IN THE OXIDIZED AND REDUCED STATES.'''
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== Function ==
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[https://www.uniprot.org/uniprot/HCP_DESDA HCP_DESDA] Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity).[HAMAP-Rule:MF_00069]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The hybrid cluster protein (HCP) from the sulfate-reducing bacteria Desulfovibrio desulfuricans ATCC 27774 has been isolated and crystallized anaerobically. The protein sample used in the crystallization studies was several months old, having been stored at 193 K, and initial crystal structure studies were unable to fully resolve details of the hybrid cluster despite the use of high-resolution data to 1.25 A collected at the ESRF, Grenoble, France. Full elucidation of the structure has only become possible with the complete knowledge of the as-isolated and fully reduced crystal structures. The analysis clarifies the significant movements in the position of the Fe atom linked to the persulfide moiety in the oxidized as-isolated protein and the S atom of the persulfide itself as the protein is reduced. The structures of the as-isolated and reduced states are discussed in terms of the putative function of the HCP proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1upx_consurf.spt"</scriptWhenChecked>
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1UPX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPX OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure of the hybrid cluster protein (HCP) from Desulfovibrio desulfuricans ATCC 27774 containing molecules in the oxidized and reduced states., Macedo S, Aragao D, Mitchell EP, Lindley P, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2065-71. Epub 2003, Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14646063 14646063]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1upx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Desulfovibrio desulfuricans]]
[[Category: Desulfovibrio desulfuricans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aragao, D.]]
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[[Category: Aragao D]]
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[[Category: Lindley, P F.]]
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[[Category: Lindley PF]]
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[[Category: Macedo, S.]]
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[[Category: Macedo S]]
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[[Category: Mitchell, E P.]]
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[[Category: Mitchell EP]]
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[[Category: Desulfovibrio desulfurican]]
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[[Category: High-resolution]]
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[[Category: Hybrid cluster]]
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[[Category: Iron]]
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[[Category: Iron-sulfur]]
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[[Category: Oxidized]]
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[[Category: Reduced]]
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[[Category: Sulphur]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:33:06 2008''
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Current revision

The crystal structure of the Hybrid Cluster Protein from Desulfovibrio desulfuricans containing molecules in the oxidized and reduced states.

PDB ID 1upx

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