Helicase 3D structures

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Current revision (08:00, 19 August 2025) (edit) (undo)
 
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Line 12: Line 12:
**[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
**[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
**[[2p6u]] - AfHel 308
**[[2p6u]] - AfHel 308
 +
**[[9b15]] - AfHel 308 (mutant)
*DNA helicase
*DNA helicase
Line 31: Line 32:
**[[7egs]] – yHel II C terminal + RNA polymerase<br />
**[[7egs]] – yHel II C terminal + RNA polymerase<br />
**[[5y59]] – yHel II subunit 2 + Sir4P peptide<br />
**[[5y59]] – yHel II subunit 2 + Sir4P peptide<br />
 +
**[[8s8p]] – yHel II subunit 1,2 + RAP1 + DNA – Cryo EM<br />
**[[3lfu]] – EcHel II <BR />
**[[3lfu]] – EcHel II <BR />
**[[2is1]], [[2is2]] - EcHel II (mutant) + DNA<BR />
**[[2is1]], [[2is2]] - EcHel II (mutant) + DNA<BR />
Line 36: Line 38:
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
**[[6ppj]], [[7lhl]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
**[[6ppj]], [[7lhl]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
 +
**[[9dqs]] – MsHel Tudor domain 731-783 <br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
 +
**[[8q3i]], [[8qn8]], [[8qu6]], [[8r2m]] – MsHel in RNA polymerase complex – Cryo EM<br />
**[[6yi2]] – EcHel 645-720 - NMR<br />
**[[6yi2]] – EcHel 645-720 - NMR<br />
**[[7egt]] – TtHel II + UvrB – ''Thermus thermophilus''<br />
**[[7egt]] – TtHel II + UvrB – ''Thermus thermophilus''<br />
 +
**[[9dci]], [[9des]] – MtHel + DNA – Cryo EM<br />
 +
 +
*DNA helicase IV or HelD
 +
 +
**[[6vsx]] – BsHelD C-terminal – ''Bacillus subtilis'' <BR />
 +
**[[6wvk]], [[6zca]], [[6zfb]], [[8xa8]] – BsHelD in RNA polymerase - Cryo EM<BR />
*ATP-dependent helicase ATRX
*ATP-dependent helicase ATRX
-
**[[3qln]] - hATRX ADD domain residues 167-289 – human<BR />
+
**[[3qln]] - hATRX ADD domain residues 167-289 <BR />
**[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
**[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
**[[3ql9]], [[4w5a]] – hATRX ADD domain + histone H3 peptide <BR />
**[[3ql9]], [[4w5a]] – hATRX ADD domain + histone H3 peptide <BR />
Line 61: Line 71:
**[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
**[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
**[[6wa8]] – EcRho + ATP<br />
**[[6wa8]] – EcRho + ATP<br />
 +
**[[9gcu]] – EcRho + ADP<br />
 +
**[[8q3n]] – EcRho + ADP – Cryo EM<br />
 +
**[[8q3p]], [[8q3q]] – EcRho (mutant) + ADP – Cryo EM<br />
 +
**[[8q3o]], [[9ff7]] – EcRho + pppGppp – Cryo EM<br />
**[[3ice]], [[8e5l]] – EcRho + ADP + BeF3 + RNA<BR />
**[[3ice]], [[8e5l]] – EcRho + ADP + BeF3 + RNA<BR />
**[[2ht1]], [[5jjl]] - EcRho + RNA<BR />
**[[2ht1]], [[5jjl]] - EcRho + RNA<BR />
Line 69: Line 83:
**[[5jjk]] – EcRho (mutant) + RNA<br />
**[[5jjk]] – EcRho (mutant) + RNA<br />
**[[1pv4]] – EcRho + DNA<br />
**[[1pv4]] – EcRho + DNA<br />
 +
**[[8ptg]] – EcRho + RNA – Cryo EM<br />
**[[1pvo]] – EcRho + ssRNA + ANPPNP<br />
**[[1pvo]] – EcRho + ssRNA + ANPPNP<br />
**[[1xpr]], [[1xpu]], [[1xpo]] - EcRho + ssRNA + antibiotic<br />
**[[1xpr]], [[1xpu]], [[1xpo]] - EcRho + ssRNA + antibiotic<br />
**[[6duq]] – EcRho + NusG + Ru12<br />
**[[6duq]] – EcRho + NusG + Ru12<br />
 +
**[[8ptm]], [[8ptn]], [[8pto]], [[8ptp]], [[8w8d]] - EcRho + ROF + ADP – Cryo EM<br />
 +
**[[8peu]], [[8pew]], [[8pex]], [[8pey]], [[9gcs]], [[9gct]] - EcRho + polarity suppression protein + ATPgS – Cryo EM<br />
**[[7x2r]] – EcRho in transcription termination complex<br />
**[[7x2r]] – EcRho in transcription termination complex<br />
**[[6xas]], [[6xav]], [[6z9p]], [[6z9s]], [[6z9t]], [[6z9q]], [[6z9r]], [[7adc]], [[7adb]], [[7add]], [[7ade]], [[8e3h]], [[8e5p]], [[8e70]] – EcRho in transcription termination complex – Cryo EM<br />
**[[6xas]], [[6xav]], [[6z9p]], [[6z9s]], [[6z9t]], [[6z9q]], [[6z9r]], [[7adc]], [[7adb]], [[7add]], [[7ade]], [[8e3h]], [[8e5p]], [[8e70]] – EcRho in transcription termination complex – Cryo EM<br />
Line 78: Line 95:
*ATP-dependent helicase MFD see [[Transcription-repair coupling factor]]
*ATP-dependent helicase MFD see [[Transcription-repair coupling factor]]
-
*ATP-dependent helicase HEPA
+
*ATP-dependent helicase HEPA or RNA polymerase-associaed protein RapA
-
**[[6bog]] – EcHEPA<br />
+
**[[6bog]], [[8so8]], [[8sp4]], [[8spg]] – EcHEPA<br />
-
**[[4s20]], [[7mkn]], [[7mkq]] – EcHEPA in RNA polymerase complex – Cryo EM<br />
+
**[[4s20]], [[7mkn]], [[7mkq]], [[8t0l]] – EcHEPA in RNA polymerase complex – Cryo EM<br />
**[[7m8e]] – EcHEPA in elongation complex – Cryo EM<br />
**[[7m8e]] – EcHEPA in elongation complex – Cryo EM<br />
Line 98: Line 115:
**[[4nw2]], [[4o42]] – hCHD1 + NS1 peptide<br />
**[[4nw2]], [[4o42]] – hCHD1 + NS1 peptide<br />
**[[2n5n]] – hCHD1 N-terminal – NMR<br />
**[[2n5n]] – hCHD1 N-terminal – NMR<br />
 +
**[[9ear]], [[9gd1]], [[9gd2]], [[9gd3]], [[9n6h]], [[9n6k]] – hCHD1 in nucleosome – Cryo EM<br />
**[[2ee1]] – hCHD4 chromodomain 2 618-674 – NMR<br />
**[[2ee1]] – hCHD4 chromodomain 2 618-674 – NMR<br />
**[[4o9i]] – hCHD4 chromodomain 1+2 499-677 <br />
**[[4o9i]] – hCHD4 chromodomain 1+2 499-677 <br />
Line 127: Line 145:
*ATP-dependent helicase GTF2F2 or general transcription factor IIF subunit 2
*ATP-dependent helicase GTF2F2 or general transcription factor IIF subunit 2
-
**[[7nvr]], [[7nvt]], [[7nvu]], [[7nvy]], [[7nvz]], [[7nw0]] – hGTF2F2 in RNA polymerase II core – Cryo EM<br />
+
**[[7nvr]], [[7nvs]], [[7nvt]], [[7nvu]], [[7nvy]], [[7nvz]], [[7nw0]], [[7zwd]], [[7zx7]], [[7zx8]], [[8bvw]], [[8byq]], [[8bz1]], [[8s51]], [[8s52]], [[8s55]], [[8s5n]], [[8wad]], [[8wak]], [[8wal]], [[8wan]], [[8wap]], [[8waq]], [[8war]], [[8was]], [[8wat]], [[8wau]], [[8wav]], [[8waw]], [[8wax]], [[8way]], [[8waz]], [[8wb0]] – hGTF2F2 in RNA polymerase II core – Cryo EM<br />
-
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]], [[6o9l]], [[7edx]], [[7eg7]], [[7eg8]], [[7eg9]], [[7ega]], [[7egb]], [[7egc]] – hGTF2F2 in core-PIC – Cryo EM<br />
+
**[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]], [[6o9l]], [[7edx]], [[7eg7]], [[7eg8]], [[7eg9]], [[7ega]], [[7egb]], [[7egc]], [[7ena]], [[7enc]], [[8gxq]], [[8gxs]] – hGTF2F2 in core-PIC – Cryo EM<br />
 +
**[[7lbm]] – hGTF2F2 in transcription complex – Cryo EM<br />
*ATP-dependent DNA helicase
*ATP-dependent DNA helicase
**[[7a8r]] – bADDH + ADP - bovine<br />
**[[7a8r]] – bADDH + ADP - bovine<br />
-
**[[8add]] – ADDH - zebrafish<br />
+
**[[8add]] – zADDH - zebrafish<br />
*ATP-dependent DNA helicase PIF1
*ATP-dependent DNA helicase PIF1
Line 139: Line 158:
**[[5fhh]], [[6hpt]] – hPIF residues 200-641<br />
**[[5fhh]], [[6hpt]] – hPIF residues 200-641<br />
**[[6hpu]], [[6hpq]], [[6hph]] – hPIF residues 206-620 + nucleotide<br />
**[[6hpu]], [[6hpq]], [[6hph]] – hPIF residues 206-620 + nucleotide<br />
 +
**[[9fb8]] – hPIF residues 206-620 + inhibitor<br />
 +
**[[9fi9]] – hPIF residues 206-620 (mutant) + inhibitor<br />
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
-
**[[5o6e]] – yPIF residues 237-780 + DNA + ADP<br />
+
**[[5o6e]], [[8xak]] – yPIF residues 237-780 + DNA + ADP<br />
**[[6s3e]], [[7ada]] – ToPIF residues 64-507 – ''Thermus oshimai''<br />
**[[6s3e]], [[7ada]] – ToPIF residues 64-507 – ''Thermus oshimai''<br />
**[[6xzt]] – ToPIF (mutant)<br />
**[[6xzt]] – ToPIF (mutant)<br />
Line 161: Line 182:
*Dead box ATP-dependent RNA helicase
*Dead box ATP-dependent RNA helicase
-
**[[4xw3]] – hDDX1 SPRY domain<br />
+
**[[4xw3]] – hDDX1 SPRY domain 72-283<br />
 +
**[[8tbx]] – hDDX1 1-74, 286-674 + ADP<br />
**[[2i4i]] – hDDX3X residues 167-581<BR />
**[[2i4i]] – hDDX3X residues 167-581<BR />
**[[4px9]] - hDDX3X residues 135-407<br />
**[[4px9]] - hDDX3X residues 135-407<br />
Line 178: Line 200:
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[3iuy]] – hDDX53<br />
**[[3iuy]] – hDDX53<br />
 +
**[[8fkp]], [[8fkq]], [[8fkr]], [[8fks]], [[8fkt]], [[8fku]], [[8fkv]], [[8fkw]], [[8fkx]], [[8fky]] – hDDX54 in pre-60S ribosome – Cryo EM<br />
**[[1vec]] – hP54 N terminal<BR />
**[[1vec]] – hP54 N terminal<BR />
**[[3fho]] – fyDbp5 – fission yeast<BR />
**[[3fho]] – fyDbp5 – fission yeast<BR />
Line 184: Line 207:
**[[2kbf]] - yDbp5 C terminal – NMR<BR />
**[[2kbf]] - yDbp5 C terminal – NMR<BR />
**[[3gfp]] - yDbp5 C-terminal<BR />
**[[3gfp]] - yDbp5 C-terminal<BR />
-
**[[2hjv]] – BsDbpA domain 2 – ''Bacillus subtilis''<BR />
+
**[[2hjv]] – BsDbpA domain 2 <BR />
**[[2g0c]] - BsDbpA RNA-binding domain<br />
**[[2g0c]] - BsDbpA RNA-binding domain<br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 <br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 <br />
Line 204: Line 227:
**[[3fht]] – hDbp5 + AMPPNP + RNA<BR />
**[[3fht]] – hDbp5 + AMPPNP + RNA<BR />
**[[6cz5]] - hDDX3X residues 132-607 + AMP<br />
**[[6cz5]] - hDDX3X residues 132-607 + AMP<br />
 +
**[[8ssw]] - hDDX3X residues 132-607 + ADP<br />
**[[6o5f]], [[7liu]] - hDDX3X + RNA<br />
**[[6o5f]], [[7liu]] - hDDX3X + RNA<br />
**[[5e7m]], [[5e7j]] – hDDX3X catalytic domain + nucleotide<br />
**[[5e7m]], [[5e7j]] – hDDX3X catalytic domain + nucleotide<br />
 +
**[[8iju]] - hDDX39A<br />
 +
**[[7znl]], [[8r7k]], [[8r7l]], [[9dlp]] - hDDX39B in TREX-2 complex – Cryo EM<br />
**[[3fe2]] – hDDX5 + ADP<br />
**[[3fe2]] – hDDX5 + ADP<br />
**[[2wax]], [[2way]], [[6f9s]] – hDDX6 C terminal + peptide<br />
**[[2wax]], [[2way]], [[6f9s]] – hDDX6 C terminal + peptide<br />
Line 247: Line 273:
**[[2xau]], [[3kx2]], [[5jpt]] – yPrp43 + nucleotide<BR />
**[[2xau]], [[3kx2]], [[5jpt]] – yPrp43 + nucleotide<BR />
**[[5i8q]] - yPrp43 + ADPNP + RNA<br />
**[[5i8q]] - yPrp43 + ADPNP + RNA<br />
 +
**[[8rdy]] - yPrp43 + Pxr1 + ADP – Cryo EM<br />
 +
**[[8enk]] – yDDX39B + Tho1 + RNA <br />
**[[5ltk]], [[5ltj]], [[5d0u]] - CtPrp43 + ADP – ''Chaetomium thermophilum''<br />
**[[5ltk]], [[5ltj]], [[5d0u]] - CtPrp43 + ADP – ''Chaetomium thermophilum''<br />
**[[5lta]] - CtPrp43 + ADP + RNA<br />
**[[5lta]] - CtPrp43 + ADP + RNA<br />
Line 255: Line 283:
**[[7pli]], [[7pmm]], [[7pmq]] - EcDbpA + RNA<br />
**[[7pli]], [[7pmm]], [[7pmq]] - EcDbpA + RNA<br />
**[[6aic]] – SaDB CSHA N-terminal + AMP <br />
**[[6aic]] – SaDB CSHA N-terminal + AMP <br />
-
**[[7ase]], [[7ask]] – DDX60 in 43S preinitiation complex complex – Trypanosoma cruzi - Cryo EM<br />
+
**[[7ase]], [[7ask]] – DDX60 in 43S preinitiation complex complex – ''Trypanosoma cruzi'' - Cryo EM<br />
* DEAH box RNA helicase
* DEAH box RNA helicase
Line 265: Line 293:
**[[6hyu]] – hDHX8 helicase domain + RNA<br />
**[[6hyu]] – hDHX8 helicase domain + RNA<br />
**[[5mqf]], [[7w59]] – hDHX8 in pre-C*-I complex – Cryo EM<br />
**[[5mqf]], [[7w59]] – hDHX8 in pre-C*-I complex – Cryo EM<br />
-
**[[3llm]] – hDHX9<br />
+
**[[3llm]] – hDHX9 NBD 329-563<br />
 +
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain 152-264 + RNA<br />
 +
**[[9mfo]], [[9mft]] – hDHX9 RNA-binding domain + inhibitor + ADP<br />
**[[5xdr]] – hDHX15 residues 110-795 (mutant)<br />
**[[5xdr]] – hDHX15 residues 110-795 (mutant)<br />
**[[8ejm]] – hDHX15 residues 110-795 + SUGP1<br />
**[[8ejm]] – hDHX15 residues 110-795 + SUGP1<br />
**[[6sh6]], [[6sh7]] – hDHX15 + Nfkb-repressing factor + ADP<br />
**[[6sh6]], [[6sh7]] – hDHX15 + Nfkb-repressing factor + ADP<br />
 +
**[[8ro2]] – hDHX15 in spliceosome – Cryo EM<br />
**[[5z58]] – hDHX16 in spliceosome – Cryo EM<br />
**[[5z58]] – hDHX16 in spliceosome – Cryo EM<br />
-
**[[2n16]] – hDHX36 G-quadruplex domain - NMR<br />
+
**[[2n16]] – hDHX36 G-quadruplex domain 53-70 - NMR<br />
**[[7a5p]] – hDHX38 in spliceosome – Cryo EM<br />
**[[7a5p]] – hDHX38 in spliceosome – Cryo EM<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
-
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
 
**[[6q6r]] – hDHX36 G-quadruplex domain + DNA <br />
**[[6q6r]] – hDHX36 G-quadruplex domain + DNA <br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
 +
**[[8vv2]], [[8vvd]] – hDHX36 48-1010 + RNA – Cryo EM<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[3eqt]]- hDHX58 residues 541-678 + RNA<br />
**[[3eqt]]- hDHX58 residues 541-678 + RNA<br />
Line 281: Line 312:
**[[5vhc]], [[5vhd]] – bDHX36 residues 150-1010 + ADP<br />
**[[5vhc]], [[5vhd]] – bDHX36 residues 150-1010 + ADP<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
 +
**[[8szp]], [[8szq]], [[8szr]], [[8szs]] – DHX9 residues 151-1151 + ADP - dog<br />
 +
**[[9mfr]] – DHX9 residues 151-1151 + inhibitor + ADP - cat<br />
 +
**[[9cpa]] – DHX29 in 43S pre-initiation complex – rabbit - Cryo EM<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[6up2]] – mDHX36 <br />
**[[6up2]] – mDHX36 <br />
Line 292: Line 326:
**[[7d4i]] – yDhr1 in 90S ribosome – Cryo EM<br />
**[[7d4i]] – yDhr1 in 90S ribosome – Cryo EM<br />
**[[6h57]] – yDhr1 <br />
**[[6h57]] – yDhr1 <br />
-
**[[6zwx]] – EcHrpA<br />
+
**[[9esh]] – fyDHX in spliceosome – Cryo EM<br />
 +
**[[6zwx]], [[8po6]] – EcHrpA<br />
**[[7akp]] – EcHrpA (mutant)<br />
**[[7akp]] – EcHrpA (mutant)<br />
**[[6zww]] – EcHrpA + RNA<br />
**[[6zww]] – EcHrpA + RNA<br />
 +
**[[8po7]], [[8po8]] – EcHrpA + DNA + ADP<br />
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />
 +
**[[8cnt]] – ThtPrp2 + ADP – ''Thermochaetoides thermophila''<br />
*ATP-dependent RNA helicase
*ATP-dependent RNA helicase
-
**[[2g9n]] - hEIF4A dead domain<br />
+
**[[2g9n]] - hEIF4A dead domain 1-406<br />
**[[5zbz]] - hEIF4A dead domain + sanguinarine<br />
**[[5zbz]] - hEIF4A dead domain + sanguinarine<br />
**[[5zc9]] - hEIF4A dead domain + ATP + RNA<br />
**[[5zc9]] - hEIF4A dead domain + ATP + RNA<br />
 +
**[[8huj]], [[9dts]] - hEIF4A dead domain + EIF4G + RNA – Cryo EM<br />
 +
**[[8xxn]] - hEIF4A dead domain in 43S ribosome – Cryo EM<br />
**[[6ieg]] - hDOB1 residues 70-1042 <br />
**[[6ieg]] - hDOB1 residues 70-1042 <br />
**[[6ro1]] - hDOB1 residues 70-1042 + NVL<br />
**[[6ro1]] - hDOB1 residues 70-1042 + NVL<br />
Line 308: Line 347:
**[[6d6r]], [[6d6q]] - hDOB1 in exosome + RNA – Cryo EM<br />
**[[6d6r]], [[6d6q]] - hDOB1 in exosome + RNA – Cryo EM<br />
**[[7z4y]] – hMTR4 in exosome – Cryo EM<br />
**[[7z4y]] – hMTR4 in exosome – Cryo EM<br />
-
**[[5z3g]], [[6c0f]], [[6cb1]], [[6em3]], [[6em4]], [[6em5]], [[7r6q]], [[7r72]], [[8e5t]], [[8etg]], [[8eti]], [[8euy]], [[8ev3]] - yHas1 in 60S ribosome biogenesis intermediate + RNA – Cryo EM<br />
+
**[[9i8v]] – zADRH in tRNA ligase complex – Cryo EM<br />
 +
**[[5z3g]], [[6c0f]], [[6cb1]], [[6em3]], [[6em4]], [[6em5]], [[7r6q]], [[7r72]], [[8e5t]], [[8esq]], [[8esr]], [[8etg]], [[8eth]], [[8eti]], [[8eup]], [[8euy]], [[8ev3]], [[8v83]], [[8v84]], [[8v85]], [[8v87]] - yHas1 in 60S ribosome biogenesis intermediate + RNA – Cryo EM<br />
**[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
**[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
**[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
**[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
Line 316: Line 356:
**[[5suq]] – ySUB2 + TEX1 + THO2 <br />
**[[5suq]] – ySUB2 + TEX1 + THO2 <br />
**[[5sup]] – ySUB2 + YRA1 + RNA <br />
**[[5sup]] – ySUB2 + YRA1 + RNA <br />
 +
**[[8u8c]] – ySUB2 + SAC3 + THP1 + SEM1 <br />
**[[7apx]], [[7luv]], [[7v2y]] – ySUB2 in THO complex – Cryo EM <br />
**[[7apx]], [[7luv]], [[7v2y]] – ySUB2 in THO complex – Cryo EM <br />
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
Line 359: Line 400:
**[[5gjb]] - ZvHel NS3 helicase domain + RNA<br />
**[[5gjb]] - ZvHel NS3 helicase domain + RNA<br />
**[[5y4z]] - ZvHel NS3 helicase domain + AMPPNP<br />
**[[5y4z]] - ZvHel NS3 helicase domain + AMPPNP<br />
-
**[[5rhg]], ]]5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]] - ZvHel NS3 helicase domain + inhibitor<br />
+
**[[5rhg]], ]]5rhh]], [[5rhi]], [[5rhj]], [[5rhk]], [[5rhl]], [[5rhm]], [[5rho]], [[5rhp]], [[5rhq]], [[5rhr]], [[5rhs]], [[5rht]], [[5rhu]], [[5rhv]], [[5rhw]], [[5rhx]], [[8um3]], [[8v7r]], [[8v7u]] - ZvHel NS3 helicase domain + inhibitor<br />
**[[5y6m]], [[5y6n]], [[6adx]], [[6ady]], [[6rwz]], [[6s0j]] - ZvHel NS3 helicase domain + ADP<br />
**[[5y6m]], [[5y6n]], [[6adx]], [[6ady]], [[6rwz]], [[6s0j]] - ZvHel NS3 helicase domain + ADP<br />
**[[7blv]], [[7nxu]] - TbevHel NS3 helicase domain + ADP <br />
**[[7blv]], [[7nxu]] - TbevHel NS3 helicase domain + ADP <br />
Line 380: Line 421:
*ATP-dependent RNA helicase Rep
*ATP-dependent RNA helicase Rep
-
**[[7lar]], [[7las]] – Rep + DNA + ADP – Porcine circovirus – Cryo EM<br />
+
**[[8h56]] – pcvRep – Porcine circovirus <br />
 +
**[[7lar]], [[7las]] – pcvRep + DNA + ADP – Cryo EM<br />
*ATP-dependent RNA helicase Repa
*ATP-dependent RNA helicase Repa
Line 407: Line 449:
**[[2fbt]] - hWRN exonuclease domain 38-236<BR />
**[[2fbt]] - hWRN exonuclease domain 38-236<BR />
**[[2fbv]], [[2fbx]], [[2fby]], [[2fc0]] - hWRN exonuclease domain + metal ion
**[[2fbv]], [[2fbx]], [[2fby]], [[2fc0]] - hWRN exonuclease domain + metal ion
 +
**[[9og3]], [[9og8]] - hWRN exonuclease domain + inhibitor
**[[3aaf]] – hWRN C terminal 949-1079 + DNA<br />
**[[3aaf]] – hWRN C terminal 949-1079 + DNA<br />
**[[6yhr]] - hWRN 517-1094<br />
**[[6yhr]] - hWRN 517-1094<br />
 +
**[[8yle]] - hWRN 517-945 + AMPPCP<br />
**[[2e6l]], [[2e6m]] - mWRN exonuclease domain
**[[2e6l]], [[2e6m]] - mWRN exonuclease domain
Line 414: Line 458:
**[[2v1x]] - hQ1 residues 49-616<BR />
**[[2v1x]] - hQ1 residues 49-616<BR />
-
**[[2wwy]], [[4u7d]] – hQ1 residues 49-616 + DNA<br />
+
**[[2wwy]], [[4u7d]], [[8yrs]] – hQ1 residues 49-616 + DNA<br />
**[[5lst]] – hQ4 residues 427-1116<br />
**[[5lst]] – hQ4 residues 427-1116<br />
**[[2kmu]] – hQ4 N terminal - NMR<br />
**[[2kmu]] – hQ4 N terminal - NMR<br />
-
**[[5lb8]] – hQ5 <br />
+
**[[5lb8]] – hQ5 11-526<br />
 +
**[[8rl6]] – hQ5 12-453 – Cryo EM<br />
**[[5lb5]], [[5lb3]] – hQ5 + ADP<br />
**[[5lb5]], [[5lb3]] – hQ5 + ADP<br />
**[[5lba]] – hQ5 + urea derivative<br />
**[[5lba]] – hQ5 + urea derivative<br />
**[[7zml]], [[7zmm]], [[7zmn]], [[7zmp]], [[7zmq]], [[7zmt]], [[7zmv]] – hQ5 + nanobody<br />
**[[7zml]], [[7zmm]], [[7zmn]], [[7zmp]], [[7zmq]], [[7zmt]], [[7zmv]] – hQ5 + nanobody<br />
 +
**[[8rl5]], [[8rla]] – hQ5 + gluebody – Cryo EM<br />
 +
**[[8rl9]] – hQ5 + GFP + gluebody – Cryo EM<br />
 +
**[[8qq2]], [[8qw8]], [[8qw9]], [[9ei1]], [[9ei2]], [[9ei3]], [[9ei4]] – hQ5 in elongation complex – Cryo EM<br />
 +
**[[9hvo]], [[9hvq]], [[9hwg]] – hQ5 in transcription complex – Cryo EM<br />
*ATP-dependent DNA helicase RecG
*ATP-dependent DNA helicase RecG
Line 449: Line 498:
**[[1c7y]], [[1bdx]] – EcRuvA + DNA<BR />
**[[1c7y]], [[1bdx]] – EcRuvA + DNA<BR />
**[[1hqc]] – TtRuvB<br />
**[[1hqc]] – TtRuvB<br />
 +
**[[8efv]], [[8efy]] – TtRuvB + DNA – Cryo EM<BR />
**[[1ixr]], [[1ixs]] – TtRuvA + RuvB (mutant) <BR />
**[[1ixr]], [[1ixs]] – TtRuvA + RuvB (mutant) <BR />
**[[1in4]] – TmRuvB<BR />
**[[1in4]] – TmRuvB<BR />
Line 455: Line 505:
**[[6blb]], [[7x5b]] - PaRuvB + ADP - ''Pseudomonas aeruginosa''<br />
**[[6blb]], [[7x5b]] - PaRuvB + ADP - ''Pseudomonas aeruginosa''<br />
**[[7x5a]], [[7x7p]], [[7x7q]] - PaRuvB in Holliday junciton – Cryo EM<br />
**[[7x5a]], [[7x7p]], [[7x7q]] - PaRuvB in Holliday junciton – Cryo EM<br />
-
**[[7pbl]], [[7pbm]], [[7pbn]], [[7pbo]], [[7pbp]], [[7pbq]], [[7pbr]], [[7pbs]], [[7pbt]], [[7pbu]] – RuvA + RuvB + DNA – Streptococcus thermophiles – Cryo EM<br />
+
**[[7pbl]], [[7pbm]], [[7pbn]], [[7pbo]], [[7pbp]], [[7pbq]], [[7pbr]], [[7pbs]], [[7pbt]], [[7pbu]] – RuvA + RuvB + DNA – ''Streptococcus thermophiles'' – Cryo EM<br />
*ATP-dependent DNA helicase RuvB-like
*ATP-dependent DNA helicase RuvB-like
Line 467: Line 517:
**[[5oaf]] – hRuvBL1 + hRuvBL2 + ADP - Cryo EM<br />
**[[5oaf]] – hRuvBL1 + hRuvBL2 + ADP - Cryo EM<br />
**[[6fo1]] – hRuvBL1 + hRuvBL2 + RPAP3 + ADP - Cryo EM<br />
**[[6fo1]] – hRuvBL1 + hRuvBL2 + RPAP3 + ADP - Cryo EM<br />
-
**[[6igm]] – hRuvBL1 + hRuvBL2 + actin-related protein + helicase SRCAP + protein - Cryo EM<br />
+
**[[6igm]], [[9ca9]] – hRuvBL1 + hRuvBL2 + actin-related protein + helicase SRCAP + protein - Cryo EM<br />
-
**[[6hts]] – hRuvBL1 + hRuvBL2 + INO80 + ARP5 + histones + DNA - Cryo EM<br />
+
**[[6hts]], [[8av6]] – hRuvBL1 + hRuvBL2 + INO80 + ARP5 + histones + DNA - Cryo EM<br />
 +
**[[9eq2]] – AtRuvBL in RT2 complex – Arabidopsis thaliana - Cryo EM<br />
**[[5oun]] – yRuvBL2 DII domain - yeast - NMR<br />
**[[5oun]] – yRuvBL2 DII domain - yeast - NMR<br />
**[[6gej]], [[6gen]] – yRuvBL1 + yRuvBL2 + vacuolar protein sorting-associated proteins + ARP6 + SWR complex protein 6 + histones + helicase SWR1 + ADP + ATP + DNA - Cryo EM<br />
**[[6gej]], [[6gen]] – yRuvBL1 + yRuvBL2 + vacuolar protein sorting-associated proteins + ARP6 + SWR complex protein 6 + histones + helicase SWR1 + ADP + ATP + DNA - Cryo EM<br />
Line 475: Line 526:
**[[6fhs]] – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES5 + ARP5 + ADP + ATP - Cryo EM<br />
**[[6fhs]] – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES5 + ARP5 + ADP + ATP - Cryo EM<br />
**[[6fml]] – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES6 + actin-related protein + histones + ADP + ATP + DNA - Cryo EM<br />
**[[6fml]] – CtRuvBL1 + CtRuvBL2 + INO80 + LES2 + LES6 + actin-related protein + histones + ADP + ATP + DNA - Cryo EM<br />
 +
**[[8ooc]] – ThtRuvBL1 + ThtRuvBL2 + INO80 + Vps72 + ADP + ATP - Cryo EM<br />
**[[5f4h]], [[5yww]] – RuvBL (mutant) - ''Sulfolobus islandicus''<br />
**[[5f4h]], [[5yww]] – RuvBL (mutant) - ''Sulfolobus islandicus''<br />
Line 485: Line 537:
**[[3upu]] – T4DDA + DNA<br />
**[[3upu]] – T4DDA + DNA<br />
 +
**[[8s9i]] – T4DDA + DT8 + Gp32 peptide<br />
 +
**[[8gme]] – T4DDA + DT17 + Gp32 <br />
 +
 +
*ATP-dependent DNA helicase DDM1
 +
 +
**[[7ux9]], [[8j90]], [[8wh5]] – AtDDM1 in nucleosome complex + DNA – Cryo EM<br />
 +
**[[8kcb]], [[8kcc]], [[8skz]], [[8wh8]], [[8wh9]], [[8wha]] – AtDDM1 in nucleosome complex + DNA + ADP – Cryo EM<br />
*ATP-dependent DNA helicase PriA
*ATP-dependent DNA helicase PriA
Line 501: Line 560:
**[[1pjr]] - GsPcrA<br />
**[[1pjr]] - GsPcrA<br />
**[[5dma]] – GsPcrA C-terminal tudor domain<br />
**[[5dma]] – GsPcrA C-terminal tudor domain<br />
 +
 +
*DNA helicase mcm8 or minichromosome maintenance 8; Domains – N-terminal 1-376; WH 770-840
 +
 +
**[[6l0o]] – hMcm8 WH domain<BR />
 +
**[[7dp3]] – hMcm8 N-terminal<BR />
 +
**[[7wi7]] – hMcm8 N-terminal + hMcm9 N-terminal <BR />
 +
**[[7w7p]], [[7yox]] – hMcm8 N-terminal + hMcm9 N-terminal – Cryo EM<BR />
 +
**[[8s94]] – hMcm8 (mutant) + hMcm9 (mutant) – Cryo EM<BR />
 +
**[[8s91]], [[8s92]] – hMcm8 N-terminal (mutant) + hMcm9 N-terminal (muant) + ADP – Cryo EM<BR />
 +
**[[8rig]] – yMcm8 + DNA – Cryo EM<BR />
 +
**[[8q67]] – Mcm (mutant) – ''Candidatus acidiphilum''<BR />
 +
*DnaB helicase or replicative DNA helicase
*DnaB helicase or replicative DNA helicase
Line 509: Line 580:
**[[2r6e]], [[2r6d]] - GsDnaB <BR />
**[[2r6e]], [[2r6d]] - GsDnaB <BR />
**[[2r5u]] – MtDnaB N terminal<BR />
**[[2r5u]] – MtDnaB N terminal<BR />
-
**[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
 
-
**[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
 
**[[2q6t]] – DnaB – ''Thermus aquaticus''<BR />
**[[2q6t]] – DnaB – ''Thermus aquaticus''<BR />
**[[1mi8]], [[6frh]] – SyDnaB – ''Synechocystis''<BR />
**[[1mi8]], [[6frh]] – SyDnaB – ''Synechocystis''<BR />
Line 517: Line 586:
**[[7t21]] – EcDnaB + DNA + ADP – Cryo EM<br />
**[[7t21]] – EcDnaB + DNA + ADP – Cryo EM<br />
**[[7t22]], [[9eco]] – EcDnaB (mutant) + DNA primase + DNA + ADP – Cryo EM<br />
**[[7t22]], [[9eco]] – EcDnaB (mutant) + DNA primase + DNA + ADP – Cryo EM<br />
 +
**[[9oa1]], [[9oa2]] – EcDnaB + helicase loader + ADP – Cryo EM<br />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
Line 528: Line 598:
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
**[[7qxm]] – VcDnaB – ''Vibrio cholerae''<br />
**[[7qxm]] – VcDnaB – ''Vibrio cholerae''<br />
 +
**[[9dls]] – VcDnaB – Cryo EM<br />
**[[6t66]] – VcDnaB + GDP <br />
**[[6t66]] – VcDnaB + GDP <br />
**[[8a3v]] – VcDnaB + DCIA<br />
**[[8a3v]] – VcDnaB + DCIA<br />
**[[4nmn]] – AaDnaB + ADP – ''Aquifex aeolicus''<br />
**[[4nmn]] – AaDnaB + ADP – ''Aquifex aeolicus''<br />
 +
 +
*DnaB-like replicative helicase or Gp41
 +
 +
**[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
 +
**[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
 +
**[[8due]] – T4DnaB-like + DNA<BR />
 +
**[[8dtp]], [[8dw6]] – T4DnaB-like + DNA – Cryo EM<BR />
 +
**[[8dvi]] – T4DnaB-like + DNA primase + DNA – Cryo EM<BR />
 +
**[[8gao]] – T4DnaB-like + DNA primase + DNA + RNA – Cryo EM<BR />
*DnaC helicase
*DnaC helicase
Line 562: Line 642:
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />
 +
**[[8ran]], [[8rao]] – ySEN1 + RNA – Cryo EM<br />
 +
**[[8ram]], [[8rap]] – ySEN1 in RNA polymerase complex – Cryo EM<br />
-
*Helicase DING
+
*Helicase DinG
-
**[[6fws]], [[6fwr]] – EcDING + DNA + ADP<br />
+
**[[6fws]], [[6fwr]] – EcDinG + DNA + ADP<br />
 +
**[[8rfj]] – DinG in crispr effector complex + DNA – ''Pseudomonas oleovorans'' – Cryo EM<br />
 +
**[[8s35]] – KpDinG in crispr effector complex + DNA – Cryo EM<br />
*Helicase SNF2
*Helicase SNF2
Line 574: Line 658:
**[[1z6a]] - SsSNF2 ATPase core
**[[1z6a]] - SsSNF2 ATPase core
-
*Helicase SKI2
+
*Helicase SKI or superkiller protein
**[[7qdy]], [[7qdz]], [[7qe0]] – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM<br />
**[[7qdy]], [[7qdz]], [[7qe0]] – hSKI2W + TPR repeat protein + SKI8 + RNA – Cryo EM<br />
**[[7qdr]], [[7qds]] – hSKI2W + TPR repeat protein + SKI8 – Cryo EM<br />
**[[7qdr]], [[7qds]] – hSKI2W + TPR repeat protein + SKI8 – Cryo EM<br />
-
**[[4buj]] – ySKI2 + superkiller protein + SKI8 <br />
+
**[[9g8m]], [[9g8n]], [[9g8o]], [[9g8p]] – hSKI2W in exosome complex – Cryo EM<br />
 +
**[[9g8r]] – hSKI2 + SKI3 + SKI8 homolog + ERFS – Cryo EM<br />
 +
**[[4buj]] – ySKI2 + SKI3 + SKI8 <br />
 +
**[[9g8q]] – ySKI2 + SKI3 + SKI8 – Cryo EM<br />
 +
**[[8q9t]], [[8qca]] – ySKI2 + SKI3 + SKI8 + RNA – Cryo EM<br />
 +
**[[8qcb]] – ySKI2 + SKI3 + SKI7 + antiviral protein SKI8 + RNA – Cryo EM<br />
 +
**[[8qcf]] – ySKI2 in exosome complex + RNA – Cryo EM<br />
**[[4a4k]] – ySKI2 insertion domain<br />
**[[4a4k]] – ySKI2 insertion domain<br />
**[[4a4z]] – ySKI2 + AMPPNP<br />
**[[4a4z]] – ySKI2 + AMPPNP<br />
**[[2va8]] – SsSKI2<br />
**[[2va8]] – SsSKI2<br />
 +
 +
*Helicase SRCAP
 +
 +
**[[9ca9]] – hSRCAP complex – Cryo EM<br />
 +
**[[9ca7]], [[9ca8]], [[9caa]], [[9cab]] – hSRCAP in nucleosome complex – Cryo EM<br />
 +
**[[8x15]], [[8x19]], [[8x1c]] – hSRCAP-C in nucleosome complex – Cryo EM<br />
*Helicase SWR1
*Helicase SWR1
**[[5i9e]] – ySWR1 + actin + actin-related protein<br />
**[[5i9e]] – ySWR1 + actin + actin-related protein<br />
 +
**[[8qku]], [[8qkv]], [[8qyv]], [[8qz0]], [[9b1d]], [[9b1e]], [[9fbw]] – ySWR1 in nucleosome – Cryo EM<br />
*Helicase XPD
*Helicase XPD
Line 629: Line 726:
**[[5gqh]] – PaCas3 + anti-crispr protein 3 <br />
**[[5gqh]] – PaCas3 + anti-crispr protein 3 <br />
**[[5b7i]] – PaCas3 + ACRF3<br />
**[[5b7i]] – PaCas3 + ACRF3<br />
 +
**[[8wtk]] – PhCas3 – ''Pyrococcus horikoshii''<br />
 +
**[[8wtl]] – PhCas3 + ATP <br />
*Helicase aquarius or intron-binding protein aquarius
*Helicase aquarius or intron-binding protein aquarius
**[[4pj3]] – hHA + AMPPNP <br />
**[[4pj3]] – hHA + AMPPNP <br />
-
**[[6id0]], [[6id1]] – hHA in spliceosome – Cryo EM<br />
+
**[[6id0]], [[6id1]], [[8i0p]], [[8i0r]]. [[8i0s]], [[8i0t]], [[8i0u]], [[8i0v]], [[8i0w]] – hHA in spliceosome – Cryo EM<br />
**[[3jb9]] – fyHA in spliceosome – Cryo EM<br />
**[[3jb9]] – fyHA in spliceosome – Cryo EM<br />

Current revision

3D structures of helicase

Updated on 19-August-2025


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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