9hl3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==TRPML1 in complex with compound 1a== | |
| - | + | <StructureSection load='9hl3' size='340' side='right'caption='[[9hl3]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9hl3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HL3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IVZ:2-[2-oxidanylidene-2-[(4~{R})-2,2,4-trimethyl-3,4-dihydroquinolin-1-yl]ethyl]isoindole-1,3-dione'>A1IVZ</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=EUJ:(2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl+dioctanoate'>EUJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hl3 OCA], [https://pdbe.org/9hl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hl3 RCSB], [https://www.ebi.ac.uk/pdbsum/9hl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hl3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Mucolipidosis type 4. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCLN1_HUMAN MCLN1_HUMAN] Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.<ref>PMID:12459486</ref> <ref>PMID:14749347</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Clark M]] | ||
| + | [[Category: Cowan SR]] | ||
| + | [[Category: Di Daniel E]] | ||
| + | [[Category: Earl CP]] | ||
| + | [[Category: Fisher S]] | ||
| + | [[Category: Holvey RS]] | ||
| + | [[Category: Jackson SM]] | ||
| + | [[Category: Johnson CN]] | ||
| + | [[Category: Lloyd-Evans E]] | ||
| + | [[Category: Mahajan P]] | ||
| + | [[Category: Morgillo CM]] | ||
| + | [[Category: Mortenson PN]] | ||
| + | [[Category: O'Reilly M]] | ||
| + | [[Category: Reeks J]] | ||
| + | [[Category: Richardson CJ]] | ||
| + | [[Category: Schopf P]] | ||
| + | [[Category: Tams DM]] | ||
| + | [[Category: Waller-Evans H]] | ||
| + | [[Category: Ward SE]] | ||
| + | [[Category: Whibley S]] | ||
| + | [[Category: Williams PA]] | ||
Current revision
TRPML1 in complex with compound 1a
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Categories: Homo sapiens | Large Structures | Clark M | Cowan SR | Di Daniel E | Earl CP | Fisher S | Holvey RS | Jackson SM | Johnson CN | Lloyd-Evans E | Mahajan P | Morgillo CM | Mortenson PN | O'Reilly M | Reeks J | Richardson CJ | Schopf P | Tams DM | Waller-Evans H | Ward SE | Whibley S | Williams PA
