9l4l

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Current revision (05:54, 1 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9l4l is ON HOLD until Paper Publication
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==Structure of human SCMCcore complex contain NLRP2==
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<StructureSection load='9l4l' size='340' side='right'caption='[[9l4l]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9l4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L4L FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l4l OCA], [https://pdbe.org/9l4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l4l RCSB], [https://www.ebi.ac.uk/pdbsum/9l4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l4l ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NALP2_HUMAN NALP2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NALP2_HUMAN NALP2_HUMAN] Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.<ref>PMID:15456791</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Han Z]]
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[[Category: Jiao HZ]]
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[[Category: Li JH]]
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[[Category: Liu QT]]
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[[Category: Ou GJ]]

Current revision

Structure of human SCMCcore complex contain NLRP2

PDB ID 9l4l

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