9lfl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of linker-extended biparatopic antibody BA1-GP4 in complex with TNFR2== | |
| - | + | <StructureSection load='9lfl' size='340' side='right'caption='[[9lfl]], [[Resolution|resolution]] 3.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9lfl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LFL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.73Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lfl OCA], [https://pdbe.org/9lfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lfl RCSB], [https://www.ebi.ac.uk/pdbsum/9lfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lfl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TNR1B_HUMAN TNR1B_HUMAN] Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.<ref>PMID:14688072</ref> <ref>PMID:12370298</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Akiba H]] | ||
| + | [[Category: Fujita J]] | ||
| + | [[Category: Kamada H]] | ||
| + | [[Category: Kanada R]] | ||
| + | [[Category: Matsumoto S]] | ||
| + | [[Category: Miyata T]] | ||
| + | [[Category: Namba K]] | ||
| + | [[Category: Ohno H]] | ||
| + | [[Category: Okuno Y]] | ||
| + | [[Category: Otsuki T]] | ||
Current revision
Cryo-EM structure of linker-extended biparatopic antibody BA1-GP4 in complex with TNFR2
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Categories: Homo sapiens | Large Structures | Mus musculus | Akiba H | Fujita J | Kamada H | Kanada R | Matsumoto S | Miyata T | Namba K | Ohno H | Okuno Y | Otsuki T
