9i20

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m (Protected "9i20" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9i20 is ON HOLD
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==Cryo-EM structure of human SLC35B1 with ADP==
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<StructureSection load='9i20' size='340' side='right'caption='[[9i20]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9i20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I20 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PEV:(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PEV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i20 OCA], [https://pdbe.org/9i20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i20 RCSB], [https://www.ebi.ac.uk/pdbsum/9i20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i20 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S35B1_HUMAN S35B1_HUMAN] ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824).<ref>PMID:30154480</ref> <ref>PMID:35041824</ref> ATP:ADP antiporter.<ref>PMID:30154480</ref> <ref>PMID:35041824</ref> ATP:ADP antiporter.<ref>PMID:30154480</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Ahn D]]
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[[Category: Drew D]]
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[[Category: Gulati A]]
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[[Category: Suades A]]

Current revision

Cryo-EM structure of human SLC35B1 with ADP

PDB ID 9i20

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