9i2b

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'''Unreleased structure'''
 
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The entry 9i2b is ON HOLD
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==SPIN90-Arp2/3 nucleated bidirectional actin filaments==
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<StructureSection load='9i2b' size='340' side='right'caption='[[9i2b]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9i2b]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I2B FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DTH:D-THREONINE'>DTH</scene>, <scene name='pdbligand=EEP:(2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic+acid+(non-preferred+name)'>EEP</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i2b OCA], [https://pdbe.org/9i2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i2b RCSB], [https://www.ebi.ac.uk/pdbsum/9i2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i2b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARP2_HUMAN ARP2_HUMAN] ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).<ref>PMID:17220302</ref> <ref>PMID:29058690</ref> <ref>PMID:29925947</ref> <ref>PMID:9000076</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Amanita phalloides]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Liu T]]
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[[Category: Moores CA]]

Current revision

SPIN90-Arp2/3 nucleated bidirectional actin filaments

PDB ID 9i2b

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