9loi

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(New page: '''Unreleased structure''' The entry 9loi is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (07:13, 15 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9loi is ON HOLD
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==Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-16==
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<StructureSection load='9loi' size='340' side='right'caption='[[9loi]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9loi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LOI FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EKA:6-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine'>A1EKA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9loi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9loi OCA], [https://pdbe.org/9loi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9loi RCSB], [https://www.ebi.ac.uk/pdbsum/9loi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9loi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Chen X]]
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[[Category: Diao X]]
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[[Category: Li F]]
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[[Category: Wu D]]
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[[Category: Zhuang J]]

Current revision

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-16

PDB ID 9loi

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