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1ykb
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ykb, resolution 2.60Å" /> '''Crystal Structure o...) |
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| - | [[Image:1ykb.gif|left|200px]]<br /> | ||
| - | <applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1ykb, resolution 2.60Å" /> | ||
| - | '''Crystal Structure of Insect Cell Expressed IL-22'''<br /> | ||
| - | == | + | ==Crystal Structure of Insect Cell Expressed IL-22== |
| - | The crystal structure of interleukin-22 expressed in Drosophila | + | <StructureSection load='1ykb' size='340' side='right'caption='[[1ykb]], [[Resolution|resolution]] 2.60Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1ykb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YKB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ykb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ykb OCA], [https://pdbe.org/1ykb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ykb RCSB], [https://www.ebi.ac.uk/pdbsum/1ykb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ykb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yk/1ykb_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ykb ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition. | ||
| - | + | Structure of insect-cell-derived IL-22.,Xu T, Logsdon NJ, Walter MR Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417<ref>PMID:15983417</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1ykb" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Logsdon NJ]] | ||
| + | [[Category: Walter MR]] | ||
| + | [[Category: Xu T]] | ||
Current revision
Crystal Structure of Insect Cell Expressed IL-22
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