9neb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The rigid portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with Pritelivir== |
| - | + | <StructureSection load='9neb' size='340' side='right'caption='[[9neb]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9neb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NEB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9neb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9neb OCA], [https://pdbe.org/9neb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9neb RCSB], [https://www.ebi.ac.uk/pdbsum/9neb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9neb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Herpesviridae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yao Q]] | ||
| + | [[Category: Yu X]] | ||
Current revision
The rigid portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex with Pritelivir
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