1yq7

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(New page: 200px<br /> <applet load="1yq7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yq7, resolution 2.20&Aring;" /> '''Human farnesyl diph...)
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[[Image:1yq7.gif|left|200px]]<br />
 
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<applet load="1yq7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yq7, resolution 2.20&Aring;" />
 
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'''Human farnesyl diphosphate synthase complexed with risedronate'''<br />
 
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==About this Structure==
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==Human farnesyl diphosphate synthase complexed with risedronate==
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1YQ7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, PO4 and RIS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YQ7 OCA].
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<StructureSection load='1yq7' size='340' side='right'caption='[[1yq7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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[[Category: Geranyltranstransferase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[1yq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YQ7 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
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[[Category: Edwards, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yq7 OCA], [https://pdbe.org/1yq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yq7 RCSB], [https://www.ebi.ac.uk/pdbsum/1yq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yq7 ProSAT]</span></td></tr>
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[[Category: Guo, K.]]
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</table>
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[[Category: Kavanagh, K.L.]]
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== Function ==
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[[Category: Oppermann, U.]]
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[[Category: SGC, Structural.Genomics.Consortium.]]
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== Evolutionary Conservation ==
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[[Category: Sundstrom, M.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: delft, F.Von.]]
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Check<jmol>
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[[Category: MG]]
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<jmolCheckbox>
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[[Category: PO4]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/1yq7_consurf.spt"</scriptWhenChecked>
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[[Category: RIS]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: bisphosphonate inhibitor]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: cholesterol biosynthesis]]
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</jmolCheckbox>
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[[Category: isoprenoid pathway]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yq7 ConSurf].
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[[Category: sgc]]
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<div style="clear:both"></div>
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:23:18 2007''
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards A]]
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[[Category: Guo K]]
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[[Category: Kavanagh KL]]
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[[Category: Oppermann U]]
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[[Category: Sundstrom M]]
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[[Category: Von delft F]]

Current revision

Human farnesyl diphosphate synthase complexed with risedronate

PDB ID 1yq7

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