7i2b

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(New page: '''Unreleased structure''' The entry 7i2b is ON HOLD Authors: Aschenbrenner, J.C., Saini, M., Chopra, A., Marples, P.G., Balcomb, B.H., Lithgo, R.M., Fearon, D., von Delft, F., Ruiz, F....)
Current revision (08:26, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7i2b is ON HOLD
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==Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z68404778 (DNV2_NS5A-x0249)==
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<StructureSection load='7i2b' size='340' side='right'caption='[[7i2b]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Aschenbrenner, J.C., Saini, M., Chopra, A., Marples, P.G., Balcomb, B.H., Lithgo, R.M., Fearon, D., von Delft, F., Ruiz, F.X., Arnold, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7i2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7I2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7I2B FirstGlance]. <br>
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Description: Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 --Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z68404778 (DNV2_NS5A-x0249)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B1A:~{N}-(4-phenylazanylphenyl)ethanamide'>B1A</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Saini, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7i2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7i2b OCA], [https://pdbe.org/7i2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7i2b RCSB], [https://www.ebi.ac.uk/pdbsum/7i2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7i2b ProSAT]</span></td></tr>
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[[Category: Lithgo, R.M]]
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</table>
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[[Category: Fearon, D]]
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== Function ==
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[[Category: Aschenbrenner, J.C]]
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[https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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[[Category: Chopra, A]]
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__TOC__
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[[Category: Ruiz, F.X]]
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</StructureSection>
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[[Category: Von Delft, F]]
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[[Category: Dengue virus 2]]
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[[Category: Arnold, E]]
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[[Category: Large Structures]]
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[[Category: Balcomb, B.H]]
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[[Category: Arnold E]]
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[[Category: Marples, P.G]]
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[[Category: Aschenbrenner JC]]
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[[Category: Balcomb BH]]
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[[Category: Chopra A]]
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[[Category: Fearon D]]
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[[Category: Lithgo RM]]
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[[Category: Marples PG]]
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[[Category: Ruiz FX]]
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[[Category: Saini M]]
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[[Category: Von Delft F]]

Current revision

Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z68404778 (DNV2_NS5A-x0249)

PDB ID 7i2b

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