9m3f
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Rc-o319 RBD/R. cornutus ACE2 complex== | |
| - | + | <StructureSection load='9m3f' size='340' side='right'caption='[[9m3f]], [[Resolution|resolution]] 2.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9m3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhinolophus_cornutus Rhinolophus cornutus] and [https://en.wikipedia.org/wiki/Sarbecovirus Sarbecovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M3F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.79Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m3f OCA], [https://pdbe.org/9m3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m3f RCSB], [https://www.ebi.ac.uk/pdbsum/9m3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m3f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A7R7AIC6_9CHIR A0A7R7AIC6_9CHIR] Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.[ARBA:ARBA00056418] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rhinolophus cornutus]] | ||
| + | [[Category: Sarbecovirus]] | ||
| + | [[Category: Matsumoto K]] | ||
| + | [[Category: Nureki O]] | ||
| + | [[Category: Shihoya W]] | ||
Current revision
Cryo-EM structure of Rc-o319 RBD/R. cornutus ACE2 complex
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