9qfu

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(New page: '''Unreleased structure''' The entry 9qfu is ON HOLD Authors: Porta, A., Manelfi, C., Talarico, C., Beccari, A.R., Brindisi, M., Summa, V., Iaconis, D., Gobbi, M., Beeg, M. Description...)
Current revision (21:55, 26 March 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9qfu is ON HOLD
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==Human Tryptase beta-2 (hTPSB2) complexed with covalent inhibitor Compound #1==
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<StructureSection load='9qfu' size='340' side='right'caption='[[9qfu]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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Authors: Porta, A., Manelfi, C., Talarico, C., Beccari, A.R., Brindisi, M., Summa, V., Iaconis, D., Gobbi, M., Beeg, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9qfu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QFU FirstGlance]. <br>
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Description: Human Tryptase beta-2 (hTPSB2) complexed with covalent inhibitor Compound #1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.983&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I52:~{N}-[(1~{S},2~{S})-6-azanyl-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxidanyl-hexan-2-yl]-4-fluoranyl-benzamide'>A1I52</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Talarico, C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qfu OCA], [https://pdbe.org/9qfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qfu RCSB], [https://www.ebi.ac.uk/pdbsum/9qfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qfu ProSAT]</span></td></tr>
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[[Category: Beccari, A.R]]
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</table>
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[[Category: Beeg, M]]
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== Function ==
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[[Category: Porta, A]]
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[https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
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[[Category: Brindisi, M]]
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__TOC__
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[[Category: Gobbi, M]]
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</StructureSection>
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[[Category: Iaconis, D]]
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[[Category: Homo sapiens]]
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[[Category: Manelfi, C]]
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[[Category: Large Structures]]
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[[Category: Summa, V]]
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[[Category: Beccari AR]]
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[[Category: Beeg M]]
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[[Category: Brindisi M]]
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[[Category: Gobbi M]]
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[[Category: Iaconis D]]
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[[Category: Manelfi C]]
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[[Category: Porta A]]
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[[Category: Summa V]]
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[[Category: Talarico C]]

Current revision

Human Tryptase beta-2 (hTPSB2) complexed with covalent inhibitor Compound #1

PDB ID 9qfu

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OCA

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