User:Elizabeth Yowell/SandboxGiavanna

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< User:Elizabeth Yowell(Difference between revisions)

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-==Your Heading Here (maybe something like 'Structure')==
+<scene name='10/1076049/Antibody/1'>Text To Be Displayed</scene>=SARS CoV-2 Protein Inhibitors (AHB2 and LCB1/LCB3)=
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page '''Elizabeth Yowell/SandboxGiavanna'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
-== Function ==
+<StructureSection load='7UHB' size='350' frame= 'true' side= 'right' caption='AHB2 Inhibitor 7UHB' scene ='10/1075216/Practice/1'>
+==Introduction==
+==Introduction==
+SARS-CoV-2 better known as Covid-19 sent the world into a [https://www.who.int/europe/emergencies/situations/covid-19 global pandemic]. In order to create a vaccine, it was essential to understand how SARS-CoV-2 infected us.
-== Disease ==
+The enzyme angiotensin converting enzyme 2 (ACE2) is attached to our cell membranes bound to a receptor binding domain (RBD) <ref name="Borkotoky">DOI:10.1007/s11033-022-08193-4</ref>. The spike protein of SARS-CoV-2 enters our bodies and binds to the RBD, allowing the spike protein access to ACE2 and our host cells <ref name=”Jackson”>DOI:10.1038/s41580-021-00418-x</ref>. Once the spike protein has access to our host cells, it is able to further infect our cells and spread the virus throughout our bodies, causing us to get sick. In order to create an effective vaccine, the pathway between the spike protein and the RBD needs to be [https://www.sciencedirect.com/science/article/pii/S0166354223000190 interrupted].
-== Relevance ==
+<scene name='10/1076049/Antibody/2'>Antibody Vaccine</scene>
-== Structural highlights ==
+<scene name='10/1076049/Antibody/4'>Antibody Binding Site</scene>
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+<scene name='10/1075216/Practice/2'>Overview Image</scene>
-</StructureSection>
+<scene name='10/1076049/Antibody_overview/1'>Antibody Overview</scene>
-== References ==
-<references/>
+Where do we begin... <ref name="Hunt">DOI: 10.1126/scitranslmed.abn1252</ref>.
+It all starts at the ACE2 receptor, but what is that? [https://www.asbmb.org/asbmb-today/science/051620/what-is-the-ace2-receptor Let's investigate!]
+[[Image:Spike with Covid.png|400 px|lef|thumb|Figure Legend: The coolest image of this protein EVAH and it was handmade!!!<ref name="Hunt">DOI: 10.1126/scitranslmed.abn1252</ref>.]]
+[[Image:LCB_Method.png|400 px|left|thumb|Figure Legend:Figure 3:The use of the De Novo protein design to create the LCB inhibitors.]]
+==Function==
+==Mechanism==
+==Active Site==
+==Inhibitor Differences==
+</StructureSection>
+==References==
+===PDB Files===
+[1]https://www.rcsb.org/structure/7UHB
+==Student Contributors==
+*Giavanna Yowell
+*Shea Bailey
+*Matthew Pereira
+<scene name='10/1076049/Ace2andrbd/1'>ACE2</scene>

Current revision

=SARS CoV-2 Protein Inhibitors (AHB2 and LCB1/LCB3)=

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AHB2 Inhibitor 7UHB

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1 Introduction
2 Introduction
3 Function
4 Mechanism
5 Active Site
6 Inhibitor Differences

Introduction

SARS-CoV-2 better known as Covid-19 sent the world into a global pandemic. In order to create a vaccine, it was essential to understand how SARS-CoV-2 infected us.

The enzyme angiotensin converting enzyme 2 (ACE2) is attached to our cell membranes bound to a receptor binding domain (RBD) ^[1]. The spike protein of SARS-CoV-2 enters our bodies and binds to the RBD, allowing the spike protein access to ACE2 and our host cells ^[2]. Once the spike protein has access to our host cells, it is able to further infect our cells and spread the virus throughout our bodies, causing us to get sick. In order to create an effective vaccine, the pathway between the spike protein and the RBD needs to be interrupted.

Where do we begin... ^[3].

It all starts at the ACE2 receptor, but what is that? Let's investigate!