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1yut

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(New page: 200px<br /> <applet load="1yut" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yut" /> '''Solution structure of Calcium-S100A13 (mini...)
Current revision (08:06, 15 May 2024) (edit) (undo)
 
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[[Image:1yut.gif|left|200px]]<br />
 
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<applet load="1yut" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1yut" />
 
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'''Solution structure of Calcium-S100A13 (minimized mean structure)'''<br />
 
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==About this Structure==
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==Solution structure of Calcium-S100A13 (minimized mean structure)==
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1YUT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YUT OCA].
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<StructureSection load='1yut' size='340' side='right'caption='[[1yut]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YUT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yut OCA], [https://pdbe.org/1yut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yut RCSB], [https://www.ebi.ac.uk/pdbsum/1yut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yut ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S10AD_HUMAN S10AD_HUMAN] Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).<ref>PMID:12746488</ref> <ref>PMID:20863990</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yu/1yut_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yut ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Structural interplay between calcium(II) and copper(II) binding to S100A13 protein., Arnesano F, Banci L, Bertini I, Fantoni A, Tenori L, Viezzoli MS, Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6341-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16145699 16145699]
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arnesano, F.]]
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[[Category: Arnesano F]]
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[[Category: Banci, L.]]
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[[Category: Banci L]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Fantoni, A.]]
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[[Category: Fantoni A]]
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[[Category: SPINE, Structural.Proteomics.in.Europe.]]
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[[Category: Tenori L]]
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[[Category: Tenori, L.]]
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[[Category: Viezzoli MS]]
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[[Category: Viezzoli, M.S.]]
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[[Category: CA]]
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[[Category: copper(ii)]]
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[[Category: ef hand calcium-binding proteins]]
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[[Category: nmr structure]]
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[[Category: s100a13]]
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[[Category: spine]]
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[[Category: structural genomics]]
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[[Category: structural proteomics in europe]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:25:05 2007''
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Current revision

Solution structure of Calcium-S100A13 (minimized mean structure)

PDB ID 1yut

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