9u6e

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'''Unreleased structure'''
 
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The entry 9u6e is ON HOLD
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==FADD-DED filaments coordinate complex IIa assembly during TNF-induced apoptosis==
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<StructureSection load='9u6e' size='340' side='right'caption='[[9u6e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Liu, P., Luo, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9u6e]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9U6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9U6E FirstGlance]. <br>
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Description: FADD-DED filaments coordinate complex IIa assembly during TNF-induced apoptosis
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9u6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9u6e OCA], [https://pdbe.org/9u6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9u6e RCSB], [https://www.ebi.ac.uk/pdbsum/9u6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9u6e ProSAT]</span></td></tr>
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[[Category: Luo, D]]
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</table>
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[[Category: Liu, P]]
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== Disease ==
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[https://www.uniprot.org/uniprot/FADD_HUMAN FADD_HUMAN] Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:[https://omim.org/entry/613759 613759]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).<ref>PMID:21109225</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FADD_HUMAN FADD_HUMAN] Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.<ref>PMID:21109225</ref> <ref>PMID:16762833</ref> <ref>PMID:19118384</ref> <ref>PMID:20935634</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Liu P]]
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[[Category: Luo D]]

Current revision

FADD-DED filaments coordinate complex IIa assembly during TNF-induced apoptosis

PDB ID 9u6e

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