9noy

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Current revision (06:06, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9noy is ON HOLD until Paper Publication
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==Human TAS1R2 transmembrane domains from the TAS1R2-TM-G protein complex==
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<StructureSection load='9noy' size='340' side='right'caption='[[9noy]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9noy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NOY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9noy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9noy OCA], [https://pdbe.org/9noy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9noy RCSB], [https://www.ebi.ac.uk/pdbsum/9noy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9noy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TS1R2_HUMAN TS1R2_HUMAN] Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In humans, the detection and ultimately the perception of sweetness begin in the oral cavity, where taste receptor cells (TRCs) dedicated to sweet-sensing interact with sugars, artificial sweeteners, and other sweet-tasting chemicals. Human sweet TRCs express on their cell surface a sweet receptor that initiates the cascade of signaling events responsible for our strong attraction to sweet stimuli. Here, we describe the cryo-electron microscopy (cryo-EM) structure of the human sweet receptor bound to two of the most widely used artificial sweeteners-sucralose and aspartame. Our results reveal the structural basis for sweet detection, provide insights into how a single receptor mediates all our responses to such a wide range of sweet-tasting compounds, and open up unique possibilities for designing a generation of taste modulators informed by the structure of the human receptor.
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Authors:
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The structure of human sweetness.,Juen Z, Lu Z, Yu R, Chang AN, Wang B, Fitzpatrick AWP, Zuker CS Cell. 2025 May 2:S0092-8674(25)00456-8. doi: 10.1016/j.cell.2025.04.021. PMID:40339580<ref>PMID:40339580</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 9noy" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang AN]]
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[[Category: Fitzpatrick AWP]]
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[[Category: Juen Z]]
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[[Category: Lu Z]]
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[[Category: Wang B]]
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[[Category: Yu R]]
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[[Category: Zuker CS]]

Current revision

Human TAS1R2 transmembrane domains from the TAS1R2-TM-G protein complex

PDB ID 9noy

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OCA

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