9o5o

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m (Protected "9o5o" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 9o5o is ON HOLD
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==Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule activator==
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<StructureSection load='9o5o' size='340' side='right'caption='[[9o5o]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9o5o]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O5O FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B8G:N-(2,1,3-benzoxadiazol-4-yl)-4-(trifluoromethyl)benzamide'>A1B8G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o5o OCA], [https://pdbe.org/9o5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o5o RCSB], [https://www.ebi.ac.uk/pdbsum/9o5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o5o ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KCNN2_HUMAN KCNN2_HUMAN] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).<ref>PMID:17157250</ref> <ref>PMID:18796614</ref> <ref>PMID:26148990</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cassell SJ]]
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[[Category: Khoshouei M]]
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[[Category: Whicher JR]]
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[[Category: Wilhelm WA]]

Current revision

Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule activator

PDB ID 9o5o

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