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1vok

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[[Image:1vok.jpg|left|200px]]
 
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==ARABIDOPSIS THALIANA TBP (DIMER)==
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The line below this paragraph, containing "STRUCTURE_1vok", creates the "Structure Box" on the page.
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<StructureSection load='1vok' size='340' side='right'caption='[[1vok]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VOK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1vok| PDB=1vok | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vok OCA], [https://pdbe.org/1vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vok RCSB], [https://www.ebi.ac.uk/pdbsum/1vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vok ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/1vok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vok ConSurf].
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<div style="clear:both"></div>
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'''ARABIDOPSIS THALIANA TBP (DIMER)'''
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==See Also==
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*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic alpha-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.
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==About this Structure==
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1VOK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA].
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==Reference==
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2.1 A resolution refined structure of a TATA box-binding protein (TBP)., Nikolov DB, Burley SK, Nat Struct Biol. 1994 Sep;1(9):621-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634102 7634102]
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Nikolov, D B.]]
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[[Category: Nikolov DB]]
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[[Category: Dna binding]]
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[[Category: Transcription factor]]
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[[Category: Transcription initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:44:12 2008''
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Current revision

ARABIDOPSIS THALIANA TBP (DIMER)

PDB ID 1vok

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