9ug9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The cryo-EM structure of 26S proteasome-Midnolin complex MB state== |
| - | + | <StructureSection load='9ug9' size='340' side='right'caption='[[9ug9]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ug9]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UG9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ug9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ug9 OCA], [https://pdbe.org/9ug9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ug9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ug9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ug9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MIDN_HUMAN MIDN_HUMAN] Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.[UniProtKB:D4AE48][UniProtKB:Q3TPJ7]<ref>PMID:37616343</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Wang HY]] | ||
| + | [[Category: Xu WQ]] | ||
Current revision
The cryo-EM structure of 26S proteasome-Midnolin complex MB state
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