Elongation factor 3D structures

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**[[1nhy]] – yEF γ N terminal<br />
**[[1nhy]] – yEF γ N terminal<br />
**[[7csl]] – PhEF α+β <br />
**[[7csl]] – PhEF α+β <br />
 +
 +
*EF-1 homolog
 +
 +
**[[8b3d]], [[8b3f]], [[9bz0]], [[9er2]], [[9fd2]] - hEFH in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
 +
**[[8tvy]] - yEFH in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
 +
**[[5xog]] - EFH in RNA pol II + Spt4/5 + RNA + DNA – ''Komagataella pastoris'' – Cryo EM<BR />
*EF-2
*EF-2
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
 +
**[[8xsx]] - hEF in 80S ribosome + tRNA + SERBP1 + drug – Cryo EM<BR />
**[[3j7p]] - pEF in 80S ribosome – Cryo EM<BR />
**[[3j7p]] - pEF in 80S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
**[[7ls1]], [[7ls2]] - mEF in 80S ribosome – Cryo EM<BR />
**[[7ls1]], [[7ls2]] - mEF in 80S ribosome – Cryo EM<BR />
 +
**[[8q87]] - EF in 80S ribosome + SERBP1 – chicken – Cryo EM<BR />
**[[4v6w]] - DmEF in 40S ribosome – Cryo EM<BR />
**[[4v6w]] - DmEF in 40S ribosome – Cryo EM<BR />
**[[7osm]] - yEF in 80S ribosome<BR />
**[[7osm]] - yEF in 80S ribosome<BR />
-
**[[5jup]], [[5jus]], [[5jut]], [[5juu]], [[6gq1]], [[7osa]] - yEF in 80S ribosome – Cryo EM<BR />
+
**[[5jup]], [[5jus]], [[5jut]], [[5juu]], [[6gq1]], [[7osa]], [[8cku]], [[8cmj]], [[8t3e]], [[8t3f]], [[8xu8]] - yEF in 80S ribosome – Cryo EM<BR />
 +
**[[8yld]], [[8ylr]] – yEF-2 + EF-3 in 80S ribosome – Cryo EM<BR />
 +
**[[8cdr]], [[8ceh]], [[8civ]] - yEF in 80S ribosome + antibiotic – Cryo EM<BR />
 +
**[[8eub]], [[8evs]], [[8ewb]] - yEF in 80S ribosome + IRES – Cryo EM<BR />
 +
**[[8evq]], [[8evr]], [[8t3a]], [[8t3b]], [[8t3c]], [[8t3d]] - yEF in 80S ribosome + IRES + antibiotic – Cryo EM<BR />
 +
**[[8umh]] - yEF in pol II complex – Cryo EM<BR />
**[[1n0v]] – yEF<BR />
**[[1n0v]] – yEF<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1u2r]] – yEF + GDP<BR />
Line 270: Line 283:
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
 +
**[[8p4d]], [[8p4f]], [[8w8f]] – hEF-Spt4 + EF-Spt5 in transcription complex – Cryo EM<br />
 +
**[[7wbv]], [[7wbw]], [[7wbx]], [[9j0o]] – hEF-Spt4 + EF-Spt5 + EF-1-homolog in transcription complex + nucleosome – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
 +
**[[8xrm]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 + EF-1-homolog in RNA polymerase II elongation complex - CryoEM<br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[7nkx]], [[7nky]] – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM<br />
**[[7nkx]], [[7nky]] – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[8ram]], [[8rap]] – yEF-Spt4 + EF-Spt5 + EF-1 in RNA polymerase II elongation complex - CryoEM<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
-
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]] – EF-Spt4 + EF-Spt5 + EF-Tfiis in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
+
**[[8p2i]] – PhEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[8oki]] – PfEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]], [[8he5]], [[8jh2]] – EF-Spt4 + EF-Spt5 + EF-11 homolog in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
 +
**[[9bct]], [[9bcu]] – EF-Spt4 + EF-Spt5 + EF-FTTA in RNA polymerase II elongation complex – ''Thermococcus kodakarensis'' - CryoEM<br />
*EF-Spt5
*EF-Spt5
 +
**[[8p4c]], [[8p4e]], [[8uis]] – hEF-Spt5 in transcription complex – Cryo EM<br />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
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**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
 +
**[[8jch]] – yEF in POL II complex – Cryo EM<br />
 +
**[[8k5p]] – yEF in POL II complex + Rai1 – Cryo EM<br />
 +
**[[8qsz]] – EF in POL II complex – fission yeast - Cryo EM<br />
 +
**[[2exu]] – yEF<BR />
**[[2exu]] – yEF<BR />
Line 297: Line 322:
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
-
**[[7oop]], [[7opc]], [[7opd]] – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM<br />
+
**[[7oop]], [[7opc]], [[7opd]], [[8oeu]], [[8oev]], [[8of0]] – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM<br />
**[[6ted]], [[7unc]], [[7und]] – pEF in RNA polymerase II transcription complex - CryoEM<br />
**[[6ted]], [[7unc]], [[7und]] – pEF in RNA polymerase II transcription complex - CryoEM<br />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
Line 312: Line 337:
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5e5b]] - hEF N-terminal<BR />
**[[5e5b]] - hEF N-terminal<BR />
 +
**[[8i17]] - hEF + histone 2A + histone 2B<BR />
*EF-M2-1
*EF-M2-1
Line 322: Line 348:
**[[5ol8]] - hEF C-terminal<br />
**[[5ol8]] - hEF C-terminal<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
 +
**[[8u8u]], [[8u8v]], [[9bdc]], [[9bdd]] - hEF + RNA polymerase + RNA + DNA – Cryo EM<br />
*EF-CA150
*EF-CA150
Line 341: Line 368:
*Elongin BC complex
*Elongin BC complex
 +
**[[1vcb]], [[8bdi]], [[8bdj]] – hEloBC + VHL<br />
 +
**[[8ei3]] – hEloBC + VHL + peptide<br />
**[[1lqb]], [[1lm8]] – hEloBC + VHL + hypoxia inducible factor 1 α<br />
**[[1lqb]], [[1lm8]] – hEloBC + VHL + hypoxia inducible factor 1 α<br />
**[[6i7q]], [[6i7r]] – hEloBC + VHL + hypoxia inducible factor 2 α<br />
**[[6i7q]], [[6i7r]] – hEloBC + VHL + hypoxia inducible factor 2 α<br />
**[[7q2j]], [[8bb2]], [[8bb3]], [[8bb4]], [[8bb5]] – hEloBC + VHL + WD repeat-containing protein 5<br />
**[[7q2j]], [[8bb2]], [[8bb3]], [[8bb4]], [[8bb5]] – hEloBC + VHL + WD repeat-containing protein 5<br />
**[[7jto]], [[7jtp]] – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor<br />
**[[7jto]], [[7jtp]] – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor<br />
-
**[[7znt]] – hEloBC + VHL + bromodomain-containing protein 4<br />
+
**[[7znt]], [[8bdx]] – hEloBC + VHL + BRD4<br />
-
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[4awj]], [[4b95]], [[4b9k]], [[4bks]], [[4bkt]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[6fmi]], [[6fmj]], [[6fmk]], [[6gfy]], [[8c13]] - hEloBC + VHL + inhibitor<br />
+
**[[8beb]], [[8ewv]] – hEloBC + VHL + BRD4 + ligand<br />
 +
**[[8pc2]] – hEloBC + VHL + FKBP5<br />
 +
**[[8fy0]], [[8fy1]], [[8fy2]] – hEloBC + VHL + Bcl-2<br />
 +
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[4awj]], [[4b95]], [[4b9k]], [[4bks]], [[4bkt]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[6fmi]], [[6fmj]], [[6fmk]], [[6gfy]], [[8bdl]], [[8bdm]], [[8bdn]], [[8bdo]], [[8c13]], [[8cqe]], [[8cqk]], [[8cql]], [[8p0f]], [[8qjs]], [[8zvj]], [[9bju]], [[9bol]], [[9gio]], [[9ipw]] - hEloBC + VHL + inhibitor<br />
**[[5t35]], [[6sis]] - hEloBC + VHL + BRD4<br />
**[[5t35]], [[6sis]] - hEloBC + VHL + BRD4<br />
-
**[[7khh]] - hEloBC + VHL + BRD4 + inhibitor<br />
+
**[[8qvu]] - hEloBC + VHL + Kras <br />
-
**[[7s4e]], [[7z6l]], [[7z76]], [[7z77]] - hEloBC + VHL + SMARCA2 + inhibitor<br /
+
**[[8qw6]], [[8qw7]] - hEloBC + VHL + Kras + inhibitor<br />
 +
**[[7khh]], [[8bdt]] - hEloBC + VHL + BRD4 + inhibitor<br />
 +
**[[8bds]] - hEloBC + VHL + BRD4 + inhibitor – Cryo EM<br />
 +
**[[7s4e]], [[7z6l]], [[7z76]], [[7z77]], [[8g1q]] - hEloBC + VHL + SMARCA2 + inhibitor<br /
**[[4wqo]] - hEloBC + VHL + cullin-2 <br />
**[[4wqo]] - hEloBC + VHL + cullin-2 <br />
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + VHL + transcription activator <br />
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + VHL + transcription activator <br />
 +
**[[8qjr]] - hEloBC + VHL + transcription activator + inhibitor <br />
**[[4ajy]] - hEloBC + hypoxia inducible factor peptide <br />
**[[4ajy]] - hEloBC + hypoxia inducible factor peptide <br />
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + VHL + hypoxia inducible factor peptide <br />
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + VHL + hypoxia inducible factor peptide <br />
 +
**[[8ebn]] - hEloBC + kelch domain-containing protein<br />
 +
**[[8sh2]] - hEloBC + kelch domain-containing protein – Cryo EM<br />
 +
**[[9d1i]], [[9d1y]], [[9d1z]] - hEloBC + ubiquitin + kelch domain-containing protein<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
 +
**[[8ij1]], [[8wqg]], [[9j77]], [[9j78]] - hEloBC + cullin-2 + RBX1 + FEM-1 – Cryo EM<br />
 +
**[[9j79]] - hEloBC + cullin-2 + RBX1 + FEM-1 + TOM20 – Cryo EM<br />
 +
**[[9lky]] - hEloBC + cullin-2 + RBX1 + FEM-1 + choline phosphatase – Cryo EM<br />
 +
**[[8jas]], [[8jau]], [[8jav]], [[8wqa]], [[8wqb]], [[8wqe]], [[8wqf]], [[8wqh]] - hEloBC + cullin-2 + RBX1 + FEM-1 + C-degron – Cryo EM<br />
 +
**[[8jaq]], [[8jar]] - hEloBC + cullin-2 + RBX1 + APP + C-degron – Cryo EM<br />
 +
**[[8je2]] - hEloBC + cullin-2 + folliculin-interacting protein + FEM-1 – Cryo EM<br />
 +
**[[8je1]] - hEloBC + cullin-2 + BEX2 + FEM-1 – Cryo EM<br />
 +
**[[8rwz]] - hEloBC + cullin-2 + RBX1 + BRD4 – Cryo EM<br />
 +
**[[8wdk]] - hEloBC + VHL + cullin-2 + RBX1 + Wee – Cryo EM<br />
 +
**[[8qu8]] - hEloBC + VHL + cullin-2 + RBX1 + Kras – Cryo EM<br />
 +
**[[8q7r]] - hEloBC + cullin-2 + RBX1 + FEM-1 + ubiquitin + Nedd8 – Cryo EM<br />
 +
**[[8r5h]] - hEloBC + cullin-2 + RBX1 + BRD4 + ubiquitin + ubiquitin conjugating enzyme – Cryo EM<br />
 +
**[[8pql]] - hEloBC + cullin-2 + RBX1 + FEM-1 + polyubiquitin + ubiquitin conjugating enzyme E2 – Cryo EM<br />
 +
**[[8rx0]] - hEloBC + cullin-2 + RBX1 + CDC34 + ubiquitin + Nedd8 – Cryo EM<br />
 +
**[[8ol1]] - hEloBC + nucleosome + cGAMP synthase + SSB-3 – Cryo EM<br />
**[[4n9f]] - hEloBC + VIF+ cullin-5 + CBF<br />
**[[4n9f]] - hEloBC + VIF+ cullin-5 + CBF<br />
**[[2ma9]] - hEloBC + VIF - NMR<br />
**[[2ma9]] - hEloBC + VIF - NMR<br />
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + VHL<br />
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + VHL<br />
 +
**[[8vlb]] - hEloBC + VHL + CDO
 +
**[[8vl9]] - hEloBC + VHL + CDO + molecular glue
**[[6zhc]] - hEloBC + VHL + Bcl-2-like protein<br />
**[[6zhc]] - hEloBC + VHL + Bcl-2-like protein<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[6c5x]], [[6i4x]], [[6i5n]], [[6i5j]] [[7m6t]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
**[[6c5x]], [[6i4x]], [[6i5n]], [[6i5j]] [[7m6t]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
 +
**[[7zlm]], [[7zln]], [[7zlo]], [[7zlp]], [[7zlr]], [[7zls]] – hEloBC + suppressor of cytokine signaling + ligand<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
 +
**[[8fvi]], [[8fvj]] - hEloBC + virion infectivity factor + CBF beta – Cryo EM<br />
 +
**[[7upn]] - hEloBC + virion infectivity factor + Ppiase – Cryo EM<br />
 +
**[[8cx0]], [[8cx1]], [[8cx2]] - hEloBC + APOBEC + virion infectivity factor + CBF b + RNA – Cryo EM<br />
 +
**[[8szk]] - hEloBC + PP2A+ virion infectivity factor + CBF b + RNA – Cryo EM<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
-
**[[1vcb]] – hEloBC + VHL<br />
+
**[[8y1u]] - hEloBC + ankyrin repeat + LZTS1 degron
**[[3zng]] – hEloBC + ASB-9 <br />
**[[3zng]] – hEloBC + ASB-9 <br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hEloBC in signalosome – Cryo EM<br />
**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hEloBC in signalosome – Cryo EM<br />
 +
**[[9d8p]] – hEloBC + kelch domain-containing protein + ubiquitin – Cryo EM<br />
**[[2fnj]] - mEloBC + GUSTAVUS
**[[2fnj]] - mEloBC + GUSTAVUS
 +
 +
*Elongin ABC complex
 +
 +
**[[8oew]] – hEloABC + RNA Pol II + RNA + DNA – Cryo EM<br />
 +
 +
*Negative EF
 +
 +
**[[1x5p]], [[2bz2]], [[2jx2]] – hNELF-E RRM domain - NMR<br />
 +
**[[5l3x]] – hNELF-A + hNELF-C/D <br />
 +
**[[8jj6]] – hNELF-B + hNELF-C/D + hNELF-E <br />
 +
**[[6gml]], [[8uha]], [[8uhd]], [[8uhg]], [[8uis]] – hNELF-F in Pol II complex – Cryo EM <br />
 +
**[[8ui0]], [[8w8e]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex – Cryo EM <br />
 +
**[[8uhg]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E + Spt5 in Pol II complex – Cryo EM <br />
 +
**[[8rbx]], [[9j0n]], [[9j0o]], [[9j0p]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex + nucleosome – Cryo EM <br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of elongation factor

Updated on 21-May-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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