9ne0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The flexible portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex prepared with forked DNA, ATP-gamma-S and Pritelivir== |
| - | + | <StructureSection load='9ne0' size='340' side='right'caption='[[9ne0]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ne0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesviridae Herpesviridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NE0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BXB:~{N}-methyl-~{N}-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)ethanamide'>A1BXB</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ne0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ne0 OCA], [https://pdbe.org/9ne0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ne0 RCSB], [https://www.ebi.ac.uk/pdbsum/9ne0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ne0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRIM_HHV11 PRIM_HHV11] Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.[HAMAP-Rule:MF_04011]<ref>PMID:7775476</ref> <ref>PMID:8189507</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Herpesviridae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yao Q]] | ||
| + | [[Category: Yu X]] | ||
Current revision
The flexible portion of Cryo-EM structure of Herpesvirus Helicase-Primase complex prepared with forked DNA, ATP-gamma-S and Pritelivir
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