1w9n

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[[Image:1w9n.gif|left|200px]]
 
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==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
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The line below this paragraph, containing "STRUCTURE_1w9n", creates the "Structure Box" on the page.
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<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=PRD_000196:EPILANCIN+15X'>PRD_000196</scene></td></tr>
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{{STRUCTURE_1w9n| PDB=1w9n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [https://pdbe.org/1w9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [https://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
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</table>
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'''ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS'''
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== Function ==
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[https://www.uniprot.org/uniprot/LAN15_STAEP LAN15_STAEP]
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__TOC__
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==Overview==
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</StructureSection>
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The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
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[[Category: Large Structures]]
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==About this Structure==
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1W9N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA].
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==Reference==
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Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15792796 15792796]
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[[Category: Single protein]]
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[[Category: Staphylococcus epidermidis]]
[[Category: Staphylococcus epidermidis]]
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[[Category: Ekkelenkamp, M.]]
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[[Category: Ekkelenkamp M]]
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[[Category: Hanssen, M G.M.]]
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[[Category: Hanssen MGM]]
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[[Category: Hsu, S T.D.]]
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[[Category: Hsu S-TD]]
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[[Category: Jong, A De.]]
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[[Category: Milatovic D]]
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[[Category: Milatovic, D.]]
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[[Category: Verhoef J]]
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[[Category: Nuland, N A.J Van.]]
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[[Category: De Jong A]]
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[[Category: Verhoef, J.]]
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[[Category: Van Nuland NAJ]]
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[[Category: Lanthionine-ring]]
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[[Category: Lantibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:07 2008''
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Current revision

Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis

PDB ID 1w9n

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