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1wcz

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[[Image:1wcz.jpg|left|200px]]
 
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==Crystal structure of an alkaline form of v8 protease from Staphylococcus aureus==
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The line below this paragraph, containing "STRUCTURE_1wcz", creates the "Structure Box" on the page.
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<StructureSection load='1wcz' size='340' side='right'caption='[[1wcz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1wcz| PDB=1wcz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcz OCA], [https://pdbe.org/1wcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wcz RCSB], [https://www.ebi.ac.uk/pdbsum/1wcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wcz ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of an alkaline form of v8 protease from Staphylococcus aureus'''
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== Function ==
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[https://www.uniprot.org/uniprot/SSPA_STAAU SSPA_STAAU] Preferentially cleaves peptide bonds on the carboxyl-terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases.<ref>PMID:1372285</ref> <ref>PMID:4627743</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1WCZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCZ OCA].
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Check<jmol>
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[[Category: Glutamyl endopeptidase]]
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<jmolCheckbox>
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[[Category: Single protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wcz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wcz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Hasegawa, T.]]
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[[Category: Hasegawa T]]
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[[Category: Kouyama, K.]]
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[[Category: Kouyama K]]
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[[Category: Murakami, M.]]
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[[Category: Murakami M]]
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[[Category: Ohta, M.]]
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[[Category: Ohta M]]
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[[Category: Torii, K.]]
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[[Category: Torii K]]
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[[Category: Yamada, K.]]
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[[Category: Yamada K]]
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[[Category: Glutamyl endopeptidase]]
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[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:29:09 2008''
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Current revision

Crystal structure of an alkaline form of v8 protease from Staphylococcus aureus

PDB ID 1wcz

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